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Zoom-in to molecular mechanisms underlying root growth and function under heterogeneous soil environment and abiotic stresses
Main conclusionThe review describes tissue-specific and non-cell autonomous molecular responses regulating the root system architecture and function...
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Quantification of absolute labeling efficiency at the single-protein level
State-of-the-art super-resolution microscopy allows researchers to spatially resolve single proteins in dense clusters. However, accurate...
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Detection of mosaic and population-level structural variants with Sniffles2
Calling structural variations (SVs) is technically challenging, but using long reads remains the most accurate way to identify complex genomic...
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Statistical Analysis of Quantitative Peptidomics and Peptide-Level Proteomics Data with Prostar
Prostar is a software tool dedicated to the processing of quantitative data resulting from mass spectrometry-based label-free proteomics....
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Short-term regulation of TSFM level does not alter amyloidogenesis and mitochondrial function in type-specific cells
BackgroundMitochondrial Ts translation elongation factor (TSFM) is an enzyme that catalyzes exchange of guanine nucleotides. By forming a complex...
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Whole-mouse clearing and imaging at the cellular level with vDISCO
Homeostatic and pathological phenomena often affect multiple organs across the whole organism. Tissue clearing methods, together with recent advances...
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RIBAP: a comprehensive bacterial core genome annotation pipeline for pangenome calculation beyond the species level
Microbial pangenome analysis identifies present or absent genes in prokaryotic genomes. However, current tools are limited when analyzing species...
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Network Reconstruction as a Novel High-Level Marker of Functional Neuronal Viability
Neuronal viability is essential for the maintenance of neuronal networks. Already slight noxious modifications, for example, the selective...
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A systems-level mass spectrometry-based technique for accurate and sensitive quantification of the RNA cap epitranscriptome
Chemical modifications of transcripts with a 5′ cap occur in all organisms and function in many aspects of RNA metabolism. To facilitate analysis of...
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Analyzing Macrophage Infection at the Organ Level
Classical in vivo infection models are oftentimes associated with speculation due to the many physiological factors that are unseen or not accounted...
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Emu: species-level microbial community profiling of full-length 16S rRNA Oxford Nanopore sequencing data
16S ribosomal RNA-based analysis is the established standard for elucidating the composition of microbial communities. While short-read 16S rRNA...
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Calcium Live Imaging at Multi-Scales from Cellular to Organ Level in Arabidopsis thaliana
Plants must adapt to environmental constraints. For this, they are able to perceive several types of stress in isolation or in combination manner. At...
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A seasonal multi-level trophic approach for bat habitat suitability assessments in peri-urban deciduous forests
Although deciduous forests are usually associated with high levels of arthropod availability, bats seem to adjust their phenological requirements...
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Three-dimensional correlative microscopy of the Drosophila female reproductive tract reveals modes of communication in seminal receptacle sperm storage
In many taxa, females store sperm in specialized storage organs. Most insect sperm storage organs have a tubular structure, typically consisting of a...
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Two-Photon Cell and Tissue Level Laser Ablation Methods to Study Morphogenetic Biomechanics
Laser ablation is routinely performed to infer mechanical tension in cells and tissues. Here we describe our method of two-photon laser ablation at...
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Bioluminescent Monitoring of Circadian Rhythms in Isolated Mesophyll Cells of Arabidopsis at Single-Cell Level
A bioluminescent monitoring system is used to detect the circadian rhythmsCircadian rhythms of individual plant Arabidopsis plants cells. Transgenic...
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Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning
A principal challenge in the analysis of tissue imaging data is cell segmentation—the task of identifying the precise boundary of every cell in an...
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Determination of the severity level of yellow rust disease in wheat by using convolutional neural networks
Yellow rust disease caused by Puccinia striiformis f. sp. tritici , a pathogen in wheat, results in significant losses in wheat production worldwide...
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Subcellular level impact of extractives on brown rot decay of Norway spruce elucidated by confocal Raman microscopy and multivariate data analysis
The influence of heartwood extractives on the chemical changes occurring during the first two weeks of brown rot decay of Norway spruce ( Picea abies) ...
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The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
The genetic and metabolic heterogeneity of RAS-driven cancers has confounded therapeutic strategies in the clinic. To address this, rapid and...
