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Comparison of ion selectivities of nitrite channel NirC and water channel aquaporin
nir C gene coding for the nitrite channel of E. coli K12 was cloned into the pET28a vector and expressed in E. coli BL21 cells. 28.5 kDa NirC monomer...
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Engineering a K+ channel ‘sensory antenna’ enhances stomatal kinetics, water use efficiency and photosynthesis
Stomata of plant leaves open to enable CO 2 entry for photosynthesis and close to reduce water loss via transpiration. Compared with photosynthesis,...
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Image-based recognition and processing system for monitoring water levels in an irrigation and drainage channel
The water level provides critically important information for disaster mitigation and water resource management. Image-based recognition and...
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Pharmacological Inhibition of AQP4 Water Channel Activity Aggravates Alpha-Synuclein Pathology in the Substantia Nigra in a Rat Model of Parkinson’s Disease
AbstractAlpha-synuclein misfolding, which leads to the formation of neurototoxic oligomers and aggregates, is one of the main causes of loss of...
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Dry-Season Water Level Shift Induced by Channel Change of the River–Lake System in China’s Largest Freshwater Lake, Poyang Lake
As a large open lake that connects to the middle reaches of Yangtze River, Poyang Lake, China, has experienced dramatic water level changes,...
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TGN-020, an Inhibitor of the Water Channel Aquaporin-4, Accelerates Nigrostriatal Neurodegeneration in the Rat Model of Parkinson’s Disease
AbstractThe water channel aquaporin-4 (AQP-4) plays a very important role in the mechanisms involved in water homeostasis in the brain and also...
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Store-Operated Calcium Channel and Inositol Triphosphate Receptor Calcium Channel Hyperactivation Inhibits Hepatocyte Autophagy to Promote Nonalcoholic Fatty Liver Disease
AbstractPreviously, we demonstrated that store-operated calcium channel (SOCC) and inositol triphosphate receptor (IP3R) calcium channel upregulation...
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Structural Mechanism of Ionic Conductivity of the TRPV1 Channel
AbstractThe so-called “hydrophobic gating” is widely discussed as a putative mechanism to control water and ion conduction via ion channels. This...
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Structure of human TRPM8 channel
TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature,...
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TMEM63B channel is the osmosensor required for thirst drive of interoceptive neurons
Thirst plays a vital role in the regulation of body fluid homeostasis and if deregulated can be life-threatening. Interoceptive neurons in the...
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Zooplankton as an indicator of hydrological connectivity of the main channel and the floodplain in a large river system
The connectivity of the river–floodplain system during floods plays a decisive role in organisms/matter contribution to the ecosystems of large...
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Water Erosion
Water erosion is the wearing away of the soil surface by water from rain, runoff, snowmelt, and irrigation. Rainwater is the main driver of water... -
Mesophotic vs. shallow water reefs: ecosystem connectivity in the Silurian of Gotland
The Lower Silurian Visby Beds (ca. 430 Ma) exposed on the island of Gotland (Sweden) yield the oldest so far described MCE’s (mesophotic coral...
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Non-radioactive Rb+ Efflux Assay for Screening KATP Channel Modulators
ATP-sensitive potassium (KATP) channels function as metabolic sensors that link cell membrane excitability to the cellular energy status by... -
Using channel pruning–based YOLOv5 deep learning algorithm for accurately counting fish fry in real time
In aquaculture, accurately counting fish fries is a prerequisite for fish population management and marketing. However, due to the fry overlap**...
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CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy
A key player of excitable cells in the heart and brain is the L-type calcium channel Ca V 1.3. In the heart, it is required for voltage-dependent Ca 2+ -s...
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Long-term memory in Staphylococcus aureus α-hemolysin ion channel kinetics
The kinetics of an ion channel are classically understood as a random process. However, studies have shown that in complex ion channels, formed by...
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Ratio of Hydrophobic–Hydrophilic and Positive–Negative Residues at Lipid–Water-Interface Influences Surface Expression and Channel Gating of TRPV1
During evolution, TRPV1 has lost, retained or selected certain residues at Lipid–Water-Interface (LWI) and formed specific patterns there. The ratio...
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Investigation of the Effect of Tamoxifen on hERG1 Potassium Channel Gene Expression in MCF-7 Cell Line
AbstractObjective: Tamoxifen (TAM) is a nonstreroidal antiestrogenic pharmaceutical agent extensively employed in the therapeutic management of...