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The lncRNA TCONS_00021785/miR-21-5p/Trim33 axis regulates VMP1-mediated zymophagy, reduces the activation of trypsinogen, and promotes acinar cell recovery
In the early stage of acute pancreatitis, trypsinogen in acinar cells is activated, and the cells clear trypsin through zymophagy to avoid damage....
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Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration
Vacuole membrane protein 1 (VMP1), the endoplasmic reticulum (ER)-localized autophagy protein, plays a key role during the autophagy process in...
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An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells
MircoRNA-21 (miR-21) was found to be highly expressed in various solid tumors, and its oncogenic properties have been extensively studied in recent...
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Palmitoylation of vacuole membrane protein 1 promotes small extracellular vesicle secretion via interaction with ALIX and influences intercellular communication
BackgroundSmall extracellular vesicles (EVs), exemplified by exosomes, mediate intercellular communication by transporting proteins, mRNAs, and...
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Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis
Vacuole membrane protein (VMP1) is a putative autophagy protein, which together with Beclin-1 acts as a molecular switch in activating autophagy. In...
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Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury
BackgroundSepsis and septic shock are life-threatening diseases with high mortality rate in intensive care unit (ICU). Acute kidney injury (AKI) is a...
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High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis
Pancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies. Metastasis is a...
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Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis
BackgroundPancreatic cancer is the fourth leading cause of cancer deaths in the United States both in females and in males, and is projected to...
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Synergistic mechanism between the endoplasmic reticulum and mitochondria and their crosstalk with other organelles
Organelles are functional areas where eukaryotic cells perform processes necessary for life. Each organelle performs specific functions; however,...
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SARS-CoV-2 biology and host interactions
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic...
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Stay in touch with the endoplasmic reticulum
The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and sheets, forms the most widely distributed membrane system in...
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Lipid droplets and cellular lipid flux
Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and...
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An innovative prognostic model based on autophagy-related long noncoding RNA signature for low-grade glioma
Autophagy is a highly conserved lysosomal degradation process essential in tumorigenesis. However, the involvement of autophagy-related long...
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Genion, an accurate tool to detect gene fusion from long transcriptomics reads
BackgroundThe advent of next-generation sequencing technologies empowered a wide variety of transcriptomics studies. A widely studied topic is gene...
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Characterization of runs of Homozygosity revealed genomic inbreeding and patterns of selection in indigenous sahiwal cattle
Runs of homozygosity (ROH) are contiguous genomic regions, homozygous across all sites which arise in an individual due to the parents transmitting...
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Evaluation of Clinically Significant miRNAs Level by Machine Learning Approaches Utilizing Total Transcriptome Data
AbstractAnalysis of the mechanisms underlying the occurrence and progression of cancer represents a key objective in contemporary clinical...
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First transcriptomic insight into the working muscles of racing pigeons during a competition flight
BackgroundThe currently known homing pigeon is a result of a sharp one-sided selection for flight characteristics focused on speed, endurance, and...
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Emerging roles of ATG proteins and membrane lipids in autophagosome formation
Autophagosome biogenesis is a dynamic membrane event, which is executed by the sequential function of autophagy-related (ATG) proteins. Upon...
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LongGF: computational algorithm and software tool for fast and accurate detection of gene fusions by long-read transcriptome sequencing
BackgroundLong-read RNA-Seq techniques can generate reads that encompass a large proportion or the entire mRNA/cDNA molecules, so they are expected...
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lncRNA PVT1: a novel oncogene in multiple cancers
Long noncoding RNAs are involved in epigenetic gene modification, including binding to the chromatin rearrangement complex in pre-transcriptional...
