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Composition and Pathogenic Potential of Mucosal Microbiota in Ulcerative Colitis
AbstractObjective: There is a large amount of data on fecal microbiome composition in inflammatory bowel disease and ulcerative colitis, but the...
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IL-22 promotes occludin expression by activating autophagy and treats ulcerative colitis
IL-22 serves a protective function in the intestinal barrier. These protective properties of IL-22 may offer a potential treatment for ulcerative...
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Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis
Ulcerative colitis (UC) is a significant inflammatory bowel disease caused by an abnormal immune response to gut microbes. However, there are still...
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Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression
Recent evidence demonstrates potential links between mitochondrial dysfunction and inflammatory bowel diseases (IBD). In addition, bidirectional...
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Chitosan functionalized Mn3O4 nanoparticles counteracts ulcerative colitis in mice through modulation of cellular redox state
Recent findings suggest a key role for reactive oxygen species (ROS) in the pathogenesis and progression of ulcerative colitis (UC). Several studies...
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Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis
Due to the lack of clinical, immunologic, genetic, and laboratory markers to predict remission in ulcerative colitis (UC) without relapse, there is...
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Circadian clock-related genome-wide mendelian randomization identifies putatively genes for ulcerative colitis and its comorbidity
BackgroundCircadian rhythm is crucial to the function of the immune system. Disorders of the circadian rhythm can contribute to inflammatory diseases...
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Identification of ulcerative colitis-specific immune cell signatures from public single-cell RNA-seq data
BackgroundSingle-cell RNA-seq enabled microscopic studies on tissue microenvironment of many diseases. Inflammatory bowel disease, an autoimmune...
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Emu Oil and zinc monoglycerolate independently reduce disease severity in a rat model of ulcerative colitis
Ulcerative colitis is characterized by colonic inflammation. Previously, Emu Oil protected the intestine against experimentally-induced inflammatory...
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Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway
As a common inflammatory bowel disease, ulcerative colitis (UC) is featured with inflammation, oxidative damage, and the impairment of intestinal...
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Production of recombinant human long-acting IL-18 binding protein: inhibitory effect on ulcerative colitis in mice
AbstractInterleukin-18 binding protein (IL-18BP) is a natural IL-18 inhibitor in vivo , which can effectively neutralize IL-18 and inhibit the...
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The development of probiotics and prebiotics therapy to ulcerative colitis: a therapy that has gained considerable momentum
Ulcerative colitis (UC) is increasingly common, and it is gradually become a kind of global epidemic. UC is a type of inflammatory bowel disease...
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Therapeutic effects of genistein in experimentally induced ulcerative colitis in rats via affecting mitochondrial biogenesis
Ulcerative colitis (UC) is an inflammatory bowel disease that affects the mucosa of the colon, resulting in severe inflammation and ulcers. Genistein...
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Protective effect and mechanism insight of purified Antarctic krill phospholipids against mice ulcerative colitis combined with bioinformatics
Antarctic krill oil is functional oil and has a complex phospholipids composition that poses difficulties in elucidating its effect mechanism on...
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Diagnosis of Crohn’s disease and ulcerative colitis using the microbiome
BackgroundInflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disease resulting from dysregulation of the mucosal immune...
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Fecal microbiota transplantation as a therapy for treating ulcerative colitis: an overview of systematic reviews
AimThe current overview on published systematic reviews (SRs) and meta-analysis (MAs) aimed to systematically gather, evaluate, and synthesize solid...
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Identification of Plant-Based Bio-Actives in the Treatment of Ulcerative Colitis Using Virtual Screening and In Vivo Approaches
Ulcerative colitis (UC) is a kind of persistent inflammatory bowel disease that is a root cause for lifelong soreness in the colon and rectum...
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Amino acids-targeted metabolomics reveals novel diagnostic biomarkers for ulcerative colitis and Crohn’s disease
Inflammatory bowel disease (IBD), which mainly comprises ulcerative colitis (UC) and Crohn’s disease (CD), is a common chronic intestinal...
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Altered fecal bile acid composition in active ulcerative colitis
BackgroundDisturbed bile acid homeostasis associated with a rise of primary and a decline of secondary bile acids is a consistent finding in...
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Single-cell and microarray chip analysis revealed the underlying pathogenesis of ulcerative colitis and validated model genes in diagnosis and drug response
The morbidity rate of ulcerative colitis (UC) in the world is increasing year by year, recurrent episodes of diarrhea, mucopurulent and bloody...
