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Synthesis, Molecular Docking, and Cytotoxicity Evaluation of New Khellinone Derivatives as Tyrosine Kinase Inhibitors
Abstract—A series of new benzofuran derivatives were synthesized using khellinone. The acetyl function of khellinone was converted into its...
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Prioritizing the Catalytic Gatekeepers through Pan- Inhibitory Mechanism of Entrectinib against ALK, ROS1 and TRKA Tyrosine Kinases
Despite the remarkable clinical activity of kinase inhibitors against anaplastic lymphoma kinase (ALK) and the closely related Ros1 and TRKA kinases,...
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O-Acetylhomoserine Sulfhydrylase from Clostridioides difficile: Role of Tyrosine Residues in the Active Site
AbstractO -acetylhomoserine sulfhydrylase is one of the key enzymes in biosynthesis of methionine in Clostridioides difficile . The mechanism of...
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Identification and biochemical characterisation of tyrosine aminotransferase from Anthoceros agrestis unveils the conceivable entry point into rosmarinic acid biosynthesis in hornworts
Main conclusionTyrosine aminotransferase (AaTAT) from the hornwort Anthoceros agrestis Paton (Anthocerotaceae) was amplified and expressed in E. coli ...
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Melanin Production by the Medicinal Mushroom Inonotus obliquus F-1375 in Submerged Liquid Cultivation and its Antiretroviral Properties
We have explored the effect of a new strain of the mushroom Inonotus obliquus (Ach.:Pers.) Pilat ( Basidiomycota ) F-1375 on melanin production in a...
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Contribution of the degradation of different hygrophytes to chromophoric dissolved organic matter during the inundation period
Hygrophytes play a key role in maintaining the structure and function of wetland and lake ecosystems. A large number of hygrophytes are submerged and...
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The contribution of microbial shikimic acid to humus formation during organic wastes composting: a review
Microbial shikimic acid is an important intermediate metabolite in the synthesis of aromatic amino acids which are precursors for forming humus...
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Dinitrosyl Iron Complexes with Glutathione Ligands Intercept Peroxynitrite and Protect Hemoglobin from Oxidative Modification
AbstractDinitrosyl iron complexes with glutathione ligands (GS-DNICs) are a physiological form of nitric oxide that is stored and transported in the...
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Peroxidase activity of rice (Oryza sativa) hemoglobin: distinct role of tyrosines 112 and 151
Five non-symbiotic hemoglobins (nsHb) have been identified in rice ( Oryza sativa ). Previous studies have shown that stress conditions can induce...
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NMR Methods to Study the Dynamics of SH2 Domain–Phosphopeptide Complexes
Nuclear magnetic resonance (NMR) spectroscopy is the method of choice for studying the dynamics of biological macromolecules in solution. By...
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Effects of mixed coniferous and broad-leaved litter on bacterial and fungal nitrogen metabolism pathway during litter decomposition
Background and aimsLitter decomposition and nitrogen metabolism are the key determinants of nutrient cycling in forest ecosystems. However, how...
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Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and incident dementia: The UK Biobank study
The plasma proteome can mediate poor oral health problems (POHP)’s link to incident dementia. We screened 37,269 UK Biobank participants 50–74 years...
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Responses of the content and spectral characteristics of dissolved organic matter in intercrop** soil to drought in northeast China
Background and aimsDissolved organic matter (DOM) has a key role in soil biogeochemistry and is vulnerable to global climate change such as drought...
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Induced defense responses in cultivated and wild chickpea genotypes against Helicoverpa armigera infestation
Five desi (GL 12,021, GL 29,095, GL 29,078, H11 22 and CSJ 515) and three wild (GLW 22, GLW 58 and GLW 187) chickpea cultivars showed induced defense...
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Relationship between microbial protein and amino acid metabolism in fermented grains of long fermentation period strong-flavor Baijiu
The long fermentation period constitutes a crucial process for enhancing the quality of base liquor in the production of Chinese strong-flavor...
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Transcriptome and metabolome analyses reveal improvement in blueberry fruit quality by interspecific grafting
Key messageOur results from transcriptomics and metabolomics extend the understanding of the consequences of interspecific grafting to improve...
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Bioinspired thiazolo-[2,3-b] quinazolin-6-one derivatives as potent anti-cancer agents targeting EGFR: their biological evaluations and in silico assessment
Cancer is a challenging and second most deadly disease. The epidermal growth factor receptors (EGFRs) dimerize upon ligand bindings to the...
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Revealing Allostery in PTPN11 SH2 Domains from MD Simulations
Src-homology 2 (SH2) domains are protein interaction domains that bind to specific peptide motifs containing phosphotyrosine. SHP2, a tyrosine...
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Targeted Screening of Fiber Degrading Bacteria with Probiotic Function in Herbivore Feces
Cellulolytic bacteria with probiotic functions play a crucial role in promoting the intestinal health in herbivores. In this study, we aimed to...
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Antibacterial and antibiofilm properties of two cyclic dipeptides produced by a new desert Streptomyces sp. HG-17 strain against multidrug-resistant pathogenic bacteria
IntroductionThe emergence of multidrug-resistant bacteria and biofilms requires discovering new antimicrobial agents from unexplored environments.
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