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Identification and functional characterization of a PDR transporter in Tripterygium wilfordii Hook.f. that mediates the efflux of triptolide
Key MessageTwPDR1, a PDR transporter from Tripterygium wilfordii Hook.f., was proved to efflux triptolide and its stability could be enhanced by A 1033...
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Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress
Triptolide (TP) exhibits therapeutic potential against multiple diseases. However, its application in clinics is limited by TP-induced hepatoxicity....
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Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis
Minimal change disease (MCD) is the common type of nephrotic syndrome (NS) in children. Currently, there is an urgent need to explore new treatments...
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Low-Dose Triptolide Enhanced Activity of Idarubicin Against Acute Myeloid Leukemia Stem-like Cells Via Inhibiting DNA Damage Repair Response
Leukemia stem cells (LSCs) are considered to be the root of relapse for acute myeloid leukemia (AML). Conventional chemotherapeutic drugs fail to...
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CYP72D19 from Tripterygium wilfordii catalyzes C-2 hydroxylation of abietane-type diterpenoids
Key messageCYP72D19, the first functional gene of the CYP72D subfamily, catalyzes the C-2 hydroxylation of abietane-type diterpenoids .
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Triptolide ameliorates fine particulate matter-induced podocytes injury via regulating NF-κB signaling pathway
BackgroundPM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury,...
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Role of Herbal Medicines for the Treatment of Arthritis
The use of herbal medicines has extensively propagated in almost every country worldwide and also in developed countries. Nowadays, various herbal...
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Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway
Bcl-2 inhibitors display an effective activity in acute myeloid leukemia (AML), but its clinical efficacy as a monotherapy was limited in part owing...
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Incorporation of CENP-A/CID into centromeres during early Drosophila embryogenesis does not require RNA polymerase II–mediated transcription
In many species, centromere identity is specified epigenetically by special nucleosomes containing a centromere-specific histone H3 variant,...
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Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia
BackgroundThe overall survival (OS) rate of adult patients suffering from acute myeloid leukaemia (AML) remains unsatisfactory at less than 40%....
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Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity
Triptolide being an active ingredient of Chinese herbal plant Tripterygium wilfordii Hook f. has severe hepatotoxicity. Previous studies from our lab...
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Promoter G-quadruplex folding precedes transcription and is controlled by chromatin
BackgroundFour-stranded G-quadruplexes (G4s) are DNA secondary structures in the human genome that are primarily found in active promoters associated...
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Natural Products Used in the Treatment of Autoimmune Disorder
Medicinal plants are promptly used in this era for the treatment of various human disorders among which one is autoimmune disorder. This is...
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Trichostatin A inhibits dendritic cell maturation through down-regulating NF—κ B (p65) pathway
BackgroundRecent evidence suggested that histone deacetylase inhibitor (HDACi) could inhibit dendritic cell (DC) maturation. However, the mechanism...
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Progress in phosphorylation of natural products
Natural medicines are a valuable resource for the development of new drugs. However, factors such as low solubility and poor bioavailability of...
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Ferroptosis: A Promising Therapeutic Target for Cardiovascular Diseases
Cardiovascular diseases (CVDs) refer to a group of conditions that affect the heart and blood vessels and are a leading cause of death worldwide....
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Herbs for Autoimmune Diseases
The incidence of autoimmune diseases worldwide is on the rise, with extensive impact on lifestyle of individuals and spiralling healthcare costs....
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Triptolide modulates tumour-colonisation and anti-tumour effect of attenuated Salmonella encoding DNase I
The strong human immunity and the associated toxicities of attenuated Salmonella severely limit the clinical use of Salmonella in tumour suppression....
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Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells
Coincident transcription and DNA replication causes replication stress and genome instability. Rapidly dividing mouse pluripotent stem cells are...
