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The Structural Features of Skeletal Muscle Titin Aggregates
Abstract —Titin is a multidomain protein of striated and smooth muscles of vertebrates. The protein consists of repeating immunoglobulin-like (Ig) and...
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Role of Titin Phosphorylation in Myocardial Stiffness Changes during Cardiomyopathies
AbstractThe review provides a brief analysis of the current knowledge of such a post-translational modification of titin as phosphorylation, with a...
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Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix
Myocardial passive stiffness is crucial for the heart’s pump function and is determined by mechanical elements, including the extracellular matrix...
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Differential Expression of Titin and Obscurin mRNA in Striated Muscles of the Long-Tailed Ground Squirrel Urocitellus undulatus
AbstractSeasonal changes in mRNA levels of the giant sarcomeric cytoskeletal proteins titin and obscurin were studied in the skeletal m....
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High-proportion spliced-in titin truncating variants in African and European ancestry in the All of Us Research Program
High-proportion spliced-in titin truncating variants (hiPSI TTNtvs) have been associated with an increased risk of atrial fibrillation, dilated...
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The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles
Muscle specific signaling has been shown to originate from myofilaments and their associated cellular structures, including the sarcomeres,...
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Alternative Splicing of Titin mRNA in Rat Soleus after Seven-Day Gravitational Unloading
AbstractChanges in titin alternative splicing in the rat soleus after seven-day gravitational unloading (the hindlimb unloading model) were studied...
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Alpha and beta myosin isoforms and human atrial and ventricular contraction
Human atrial and ventricular contractions have distinct mechanical characteristics including speed of contraction, volume of blood delivered and the...
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Changes in Titin Structure during Its Aggregation
AbstractIn this paper, the property of the muscle titin protein to form in vitro specific amyloid-like aggregates is discussed. The main difference...
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The Molecular Basis of the Frank-Starling Law of the Heart: A Possible Role for PIEZO1?
The Frank-Starling Law was proposed over 100 years ago, but it remains to be fully explained at the molecular level. The Law states that when the...
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Transcriptomic profiles of muscular dystrophy with myositis (mdm) in extensor digitorum longus, psoas, and soleus muscles from mice
BackgroundTitinopathies are inherited muscular diseases triggered by genetic mutations in the titin gene. Muscular dystrophy with myositis ( mdm ) is...
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Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading
AbstractThe effect of HDACs 4 and 5 on the level of atrophy, calpain-1 and titin content, and TTN gene expression in rat soleus after 7-day...
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Sex-specific cardiovascular remodeling leads to a divergent sex-dependent development of heart failure in aged hypertensive rats
IntroductionThe prevalence of heart failure with preserved ejection fraction (HFpEF) is continuously rising and predominantly affects older women...
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ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NFκB
The muscular dystrophy with myositis ( mdm) mouse model results in a severe muscular dystrophy due to an 83-amino-acid deletion in the N2A region of...
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The 50th anniversary of the European Society for Muscle Research: a journey through half a century of scientific advances
The European Society for Muscle Research (ESMR) started in 1971 as “European Muscle Club” in a joint initiative of Marcus Schaub, Eduard Jenny and...
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Murf1 alters myosin replacement rates in cultured myotubes in a myosin isoform–dependent manner
Skeletal muscle tissue increases or decreases its volume by synthesizing or degrading myofibrillar proteins. The ubiquitin–proteasome system plays a...
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Cardiac sarcomere mechanics in health and disease
The sarcomere is the fundamental structural and functional unit of striated muscle and is directly responsible for most of its mechanical properties....
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Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues
Noonan syndrome (NS), the most common among RASopathies, is caused by germline variants in genes encoding components of the RAS-MAPK pathway....
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Stable Level of Giant Sarcomeric Cytoskeletal Proteins in Striated Muscles of the Edible Dormouse Glis glis during Hibernation
AbstractThe changes in the content of the giant sarcomeric cytoskeletal proteins titin (3000–3700 kDa) and nebulin (770 kDa) in skeletal muscles ( m....
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Basic Structure of Skeletal Muscle
Building on the foundational understanding established in the first chapter, Chap. 2 explores the burgeoning...