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1. Regulated Expression of an Environmental DNA-Derived Type II Polyketide Gene Cluster in Streptomyces Hosts Identified a New Tetracenomycin Derivative TCM Y

   As bacterial natural products have been proved to be the most important source of many therapeutic medicines, the need to discover novel natural...

   Lishuang Nie, Mingming Cao, ... Zhiyang Feng in Current Microbiology

   Article 06 October 2022
   

2. Amycolatopsis camponoti sp. nov., new tetracenomycin-producing actinomycete isolated from carpenter ant Camponotus vagus

   An actinobacterial strain A23 ^T , isolated from adult ant Camponotus vagus collected in Ryazan region (Russia) and established as tetracenomycin X...

   Yuliya V. Zakalyukina, Ilya A. Osterman, ... Mikhail V. Biryukov in Antonie van Leeuwenhoek

   Article Open access 26 February 2022
   

3. Genome mining and description of Streptomyces albidus sp. nov., an endophytic actinobacterium with antibacterial potential

   An endophytic actinobacterium, strain CAP215 ^T was isolated from the root sample of a native pine tree ( Callitris preissii ), Adelaide, South...

   Onuma Kaewkla, Christopher Milton Mathew Franco in Antonie van Leeuwenhoek

   Article 04 March 2021
   

4. The antitumor antibiotic mithramycin: new advanced approaches in modification and production

   Abstract

   The aureolic acid-type polyketide mithramycin (MTM) has a remarkable cytotoxicity against a variety of human tumors and has been used for the...

   Jan Kormanec, Renata Novakova, ... Dagmar Homerova in Applied Microbiology and Biotechnology

   Article 20 July 2020
   

5. Genome insights into the pharmaceutical and plant growth promoting features of the novel species Nocardia alni sp. nov

   Background

   Recent studies highlighted the biosynthetic potential of nocardiae to produce diverse novel natural products comparable to that of Streptomyces...

   Imen Nouioui, Sung-min Ha, ... Michael Goodfellow in BMC Genomics

   Article Open access 21 January 2022
   

6. Physiological analysis of the improved ε-polylysine production induced by reactive oxygen species

   Abstract Introduction

   Epsilon-poly-L-lysine (ε-PL) is produced by Streptomyces species in acidic and aerobic conditions, which inevitably induces...

   Chao** Yue, Zhiwei Su, ... **n Zeng in Applied Microbiology and Biotechnology

   Article 31 December 2022
   

7. Unveiling the bioactive potential of Actinomycetota from the Tagus River estuary

   The increase in global travel and the incorrect and excessive use of antibiotics has led to an unprecedented rise in antibiotic resistance in...

   José Diogo Neves dos Santos, Eugénia Pinto, ... Olga Maria Lage in International Microbiology

   Article Open access 18 January 2024
   

8. Artificial microRNA mediated silencing of cyclase and aldo–keto reductase genes reveal their involvement in the plumbagin biosynthetic pathway

   Plumbagin and other naphthoquinone derivatives from the Plumbago zeylanica L. (Plumbaginaceae) are known for their anticancer and other medicinal...

   Arati P. Vasav, Balu G. Meshram, ... Vitthal T. Barvkar in Journal of Plant Research

   Article 13 October 2022
   

9. Synthetic macrolides overcoming MLS_BK-resistant pathogens

   Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS _B K) antibiotics are unable to counter the growing challenge of antibiotic resistance...

   Cong-Xuan Ma, Ye Li, ... Jian-Hua Liang in Cell Discovery

   Article Open access 11 July 2024
   

10. Structures of the ribosome bound to EF-Tu–isoleucine tRNA elucidate the mechanism of AUG avoidance

    The frequency of errors upon decoding of messenger RNA by the bacterial ribosome is low, with one misreading event per 1 × 10 ⁴ codons. In the...

    Mariia Yu. Rybak, Matthieu G. Gagnon in Nature Structural & Molecular Biology

    Article 27 March 2024
    

11. A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis

    Abstract

    Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor, antiviral, anti-inflammatory, and antiparasitic...

    S. E. Dmitriev, D. O. Vladimirov, K. A. Lashkevich in Biochemistry (Moscow)

    Article Open access 26 November 2020
    

12. Microbial Enzymes in the Bioremediation of Pollutants: Emerging Potential and Challenges

    The quality of life on the Earth is linked inextricably to the overall quality of the environment. Unfortunately the progress in science and...

    Geeta Bhandari, Mukund Sharma in Mycoremediation and Environmental Sustainability

    Chapter 2021
    

13. Application of Enzymes in Bioremediation of Contaminated Hydrosphere and Soil Environment

    Due to the ever-increasing global population, industrial sector is growing at a rapid rate which is leading to increase in discharge of hazardous and...

    Sanchita Gupta, Lalit Dangi, ... Radha Rani in Bioprospecting of Enzymes in Industry, Healthcare and Sustainable Environment

    Chapter 2021
    

14. Discovery of “heat shock metabolites” produced by thermotolerant actinomycetes in high-temperature culture

    In actinomycetes, many secondary metabolite biosynthetic genes are not expressed under typical laboratory culture conditions and various efforts have...

    Shun Saito, Wataru Kato, ... Masaya Imoto in The Journal of Antibiotics

    Article 03 February 2020
    

15. Type III Polyketide Synthases: Current State and Perspectives

    Microorganisms produce an array of secondary metabolites primarily for their growth, self-defense, communication, and survival in natural...

    Thangamani Rajesh, Manish K. Tiwari, ... Marimuthu Jeya in Microbial Technology for the Welfare of Society

    Chapter 2019
    

16. Chalcone synthases (CHSs): the symbolic type III polyketide synthases

    Main conclusion

    Present review provides a thorough insight on some significant aspects of CHSs over a period of about past three decades with a better...

    Shahzad A. Pandith, Salika Ramazan, ... Manzoor A. Shah in Planta

    Article 27 November 2019
    

17. Advancement of Biotechnology by Genetic Modifications

    One of the greatest sources of metabolic and enzymatic diversity are microorganisms. In recent years, emerging recombinant DNA and genomic techniques...

    Arnold L. Demain, Sergio Sánchez in Microbial Carotenoids

    Protocol 2018
    

18. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation

    Seventeen new compounds, naphthacemycins A ₁ –A ₁₁ , B ₁ –B ₄ and C ₁ –C ₂ , were isolated from a cultured broth of Streptomyces sp. KB-3346-5 during screening...

    Atsushi Fukumoto, Yong-Pil Kim, ... Kazuro Shiomi in The Journal of Antibiotics

    Article 15 March 2017
    

19. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities

    Screening for circumventors of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) led us to find 17 novel antibiotics,...

    Atsushi Fukumoto, Yong-Pil Kim, ... Kazuro Shiomi in The Journal of Antibiotics

    Article 15 March 2017
    

20. An overview of rapamycin: from discovery to future perspectives

    Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its...

    Young Ji Yoo, Hanseong Kim, ... Yeo Joon Yoon in Journal of Industrial Microbiology & Biotechnology

    Article 09 September 2016