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Establishment of an in vitro model of monocyte-like THP-1 cells for trained immunity induced by bacillus Calmette-Guérin
BackgroundMycobacteria bloodstream infections are common in immunocompromised people and usually have disastrous consequences. As the primary...
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Rotenone-induced oxidative stress in THP-1 cells: biphasic effects of baicalin
BackgroundSeveral results demonstrated that microglia and peripheral monocytes/macrophages infiltrating the central nervous system (CNS) are involved...
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Anti-inflammatory effects of α-humulene on the release of pro-inflammatory cytokines in lipopolysaccharide-induced THP-1 cells
While acute inflammation is an essential physical response to harmful external influences, the transition to chronic inflammation is problematic and...
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Differentiation, maturation, and collection of THP-1-derived dendritic cells based on a PEG hydrogel culture platform
PurposeDendritic cell (DC) is a spearhead responsible for immune response and surrounded by extracellular matrix in three-dimensional (3D) tissue....
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The deposition of lanthanum carbonate may activate macrophages to induce gastrointestinal mucosal injury in patients with chronic kidney disease: an in vitro caco-2/THP-1 macrophage coculture model study
The aim of this study was to investigate the effect and possible underlying mechanism of La 2 (CO 3 ) 3 deposition on GI mucosal inflammation. Our results...
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The Protective Action of Hsp70 and Hydrogen Sulfide Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory Response by Modulating Endocytosis
Abstract —Hsp70 and hydrogen sulfide donors reduce inflammatory processes in human and animal cells. The biological action mediated by Hsp70 and H 2 S...
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In vitro phenotypic effects of Lipoxin A4 on M1 and M2 polarized macrophages derived from THP-1
BackgroundLipoxin A4 (LXA4) is a specialized pro-resolving mediator involved in the resolution phase of inflammation that is crucial for the return...
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Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells
AbstractMelatonin ( N -acetyl-5-methoxytryptamine, MEL) is a hormone synthesized by the pineal gland. Due to its oncostatic effect, it can be...
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Investigating the Effects of Biogenic Zinc Oxide Nanoparticles Produced Using Papaver somniferum Extract on Oxidative Stress, Cytotoxicity, and the Induction of Apoptosis in the THP-1 Cell Line
This study investigated the effect of novel zinc oxide nanoparticles (ZnO NPs) biosynthesized employing Papaver somniferum leaf on oxidative stress,...
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Enzyme-digested Colla Corii Asini (E’jiao) suppresses lipopolysaccharide-induced inflammatory changes in THP-1 macrophages and OP9 adipocytes
Gut microbial lipopolysaccharides (LPS)-induced inflammatory responses in adipose tissue are associated with the dysfunction of adipocytes, insulin...
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Monocytic THP-1 cells diverge significantly from their primary counterparts: a comparative examination of the chromosomal conformations and transcriptomes
Immortalized cell lines have long been used as model systems to systematically investigate biological processes under controlled and reproducible...
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Effects of the media conditioned by various macrophage subtypes derived from THP-1 cells on tunneling nanotube formation in pancreatic cancer cells
BackgroundTunneling nanotubes (TNTs) are special membrane structures for intercellular communications. Vital cargoes (such as mitochondria) could be...
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TRIM64 promotes ox-LDL-induced foam cell formation, pyroptosis, and inflammation in THP-1-derived macrophages by activating a feedback loop with NF-κB via IκBα ubiquitination
Atherosclerosis is a chronic inflammatory disease and the main pathology behind most cardiovascular diseases and the overactivation of macrophages...
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NF-κB/ABCA1 pathway aggravates ox-LDL-induced cell pyroptosis by activation of NLRP3 inflammasomes in THP-1-derived macrophages
ObjectiveNF-κB (nuclear transcription factor-kappa B) plays a well-known function in the regulation of immune responses and inflammation, but growing...
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Paeoniflorin reduces the inflammatory response of THP-1 cells by up‐regulating microRNA-124
BackgroundThe activation of macrophages and the release of inflammatory cytokines are the main reasons for the progress of systemic lupus...
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The effects of Leishmania RNA virus 2 (LRV2) on the virulence factors of L. major and pro-inflammatory biomarkers: an in vitro study on human monocyte cell line (THP-1)
BackgroundCutaneous Leishmaniasis (CL) is a parasitic disease with diverse outcomes. Clinical diversity is influenced by various factors such as Leishmania...
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Mycobacterium tuberculosis Infection of THP-1 Cells : A Model for High Content Analysis of Intracellular Growth and Drug Susceptibility
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of death from any infectious agent worldwide, with...
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Levels of Zinc Transporters mRNA Depending on Zinc Status and HIV-1 Tat Induced Inflammation in Muscle (Rhabdomyosarcoma) and Monocyte (THP-1) Cell Lines
AbstractMonocytes and muscles demonstrate functionally contrasting behavior under conditions of zinc deficiency with relation to zinc storage system...
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MiR-146a Negatively Regulates Aspergillus fumigatus-Induced TNF-α and IL-6 Secretion in THP-1 Macrophages
Aspergillus fumigatu ( A. fumigatus ) is one of the most common important fungal pathogens that cause life-threatening infectious disease in...
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Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages
Mitochondrial dysfunction plays a crucial role in the central pathogenesis of insulin resistance and type 2 diabetes mellitus. Macrophages play...
