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Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage
BackgroundThe current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of...
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Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)
BackgroundCynomolgus macaque ( Macaca fascicularis ) is an attractive animal model for the study of human disease and is extensively used in...
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TCR-L: an analysis tool for evaluating the association between the T-cell receptor repertoire and clinical phenotypes
BackgroundT cell receptors (TCRs) play critical roles in adaptive immune responses, and recent advances in genome technology have made it possible to...
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Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals
SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the...
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scRNA-seq revealed the special TCR β & α V(D)J allelic inclusion rearrangement and the high proportion dual (or more) TCR-expressing cells
Allelic exclusion, one lymphocyte expresses one antigen receptor, is a fundamental mechanism of immunological self-tolerance and highly specific...
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Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity
T cell receptor (TCR) repertoires are critical for antiviral immunity. Determining the TCR repertoire composition, diversity, and dynamics and how...
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GENTLE: a novel bioinformatics tool for generating features and building classifiers from T cell repertoire cancer data
BackgroundIn the global effort to discover biomarkers for cancer prognosis, prediction tools have become essential resources. TCR (T cell receptor)...
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Repertoire analysis of γδ T cells in the chicken enables functional annotation of the genomic region revealing highly variable pan-tissue TCR gamma V gene usage as well as identifying public and private repertoires
BackgroundDespite increasing interest in γδ T cells and their non-classical behaviour, most studies focus on animals with low numbers of circulating...
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Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding
T cell differentiation in the thymus generates CD4 + helper and cytotoxic CD8 + cells as the two principal T cell lineages. Curiously, at the end of...
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HeteroTCR: A heterogeneous graph neural network-based method for predicting peptide-TCR interaction
Identifying interactions between T-cell receptors (TCRs) and immunogenic peptides holds profound implications across diverse research domains and...
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Anchor Clustering for million-scale immune repertoire sequencing data
BackgroundThe clustering of immune repertoire data is challenging due to the computational cost associated with a very large number of pairwise...
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Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that...
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Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
BackgroundIn rheumatoid arthritis (RA), the activation of T and B cell clones specific for self-antigens leads to the chronic inflammation of the...
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Single-cell T-cell receptor repertoire profiling in dogs
Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses in these models requires reagents...
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Signatures of T cell immunity revealed using sequence similarity with TCRDivER algorithm
Changes in the T cell receptor (TCR) repertoires have become important markers for monitoring disease or therapy progression. With the rise of...
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Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins
Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable...
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Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response
Personalized immunotherapy targeting tumor-specific antigens (TSAs) could generate efficient and safe antitumor immune response without damaging...
