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A DNA Origami-Based Biointerface to Interrogate the Spatial Requirements for Sensitized T-Cell Antigen Recognition
When T cells scan the surface of antigen-presenting cells (APCs), they can detect the presence of just a few antigenic peptide/MHC complexes (pMHCs),...
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Large scale genomic rearrangements in selected Arabidopsis thaliana T-DNA lines are caused by T-DNA insertion mutagenesis
BackgroundExperimental proof of gene function assignments in plants is based on mutant analyses. T-DNA insertion lines provided an invaluable...
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Unified mRNA Subcellular Localization Predictor based on machine learning techniques
BackgroundThe mRNA subcellular localization bears substantial impact in the regulation of gene expression, cellular migration, and adaptation....
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JAGGER localization and function are dependent on GPI anchor addition
Key messageGPI anchor addition is important for JAGGER localization and in vivo function. Loss of correct GPI anchor addition in JAGGER, negatively...
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Genome-Wide Analysis of DNA Methylation in Cd4+ T Lymphocytes of Patients with Primary Progressive Multiple Sclerosis Indicates Involvement of This Epigenetic Process in the Disease Immunopathogenesis
AbstractThe pathogenesis of multiple sclerosis (MS), a chronic disease of the CNS, includes autoimmune and neurodegenerative components. In most...
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System-wide analysis of RNA and protein subcellular localization dynamics
Although the subcellular dynamics of RNA and proteins are key determinants of cell homeostasis, their characterization is still challenging. Here we...
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Genetically encoded multimeric tags for subcellular protein localization in cryo-EM
Cryo-electron tomography (cryo-ET) allows for label-free high-resolution imaging of macromolecular assemblies in their native cellular context....
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Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer
Mutation-induced malfunction of ten-eleven translocation methylcytosine dioxygenase 2 (TET2) is widely reported in haematological malignancies....
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MINSTED nanoscopy enters the Ångström localization range
Super-resolution techniques have achieved localization precisions in the nanometer regime. Here we report all-optical, room temperature localization...
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MSLP: mRNA subcellular localization predictor based on machine learning techniques
BackgroundSubcellular localization of messenger RNA (mRNAs) plays a pivotal role in the regulation of gene expression, cell migration as well as in...
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Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
Manipulation of the subcellular localization of transcription factors by preventing their shuttling via the nuclear pore complex (NPC) emerges as a...
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Determining the Subcellular Localization of Proteins in the Different Membranes of Diatom Secondary Plastid
Diatoms such as Phaeodactylum tricornutum arose through a process termed secondary endosymbiosis, in which red alga–derived plastids are surrounded...
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Co-localization of clusters of TCR-regulated genes with TAD rearrangements
BackgroundGene expression has long been known to be influenced by the relative proximity of DNA regulatory elements. Topologically associating...
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Differential cellular localization of DNA gyrase and topoisomerase IB in response to DNA damage in Deinococcus radiodurans
Topoisomerases are crucial enzymes in genome maintenance that modulate the topological changes during DNA metabolism. Deinococcus radiodurans , a...
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DBlink: dynamic localization microscopy in super spatiotemporal resolution via deep learning
Single-molecule localization microscopy (SMLM) has revolutionized biological imaging, improving the spatial resolution of traditional microscopes by...
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Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS
Tumor cells evade targeted drugs by rewiring their genetic and epigenetic networks. Here, we identified that inhibition of MAPK signaling rapidly...
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Application of RNA interference and protein localization to investigate housekee** and developmentally regulated genes in the emerging model protozoan Paramecium caudatum
Unicellular eukaryotes represent tremendous evolutionary diversity. However, the molecular mechanisms underlying this diversity remain largely...
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Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes
Ca 2+ sparks constitute the fundamental units of Ca 2+ release in cardiomyocytes. Here we investigate how ryanodine receptors (RyRs) collectively...
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Controlling the Subcellular Localization of Signaling Proteins Using Chemically Induced Dimerization and Optogenetics
A given protein can perform numerous roles in a cell with its participation in protein complexes and distinct localization within the cell playing a...
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Scanning single molecule localization microscopy (scanSMLM) for super-resolution volume imaging
Over the last decade, single-molecule localization microscopy (SMLM) has developed into a set of powerful techniques that have improved spatial...
