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Induction of glioblastoma invasion triggered by system Xc−-mediated glutamate release
BackgroundsGlioblastoma (GBM) is a highly aggressive brain cancer associated with poor prognosis, primarily attributed to its profound invasive...
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Nrf2 suppresses erastin-induced ferroptosis through activating system Xc(-) in ovarian cancer
BackgroundOvarian cancer (OV) is a gynecologic tumor with high mortality due to its drug resistance. In most cases, simple standard care is not...
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GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc–/GSH/GPX4
The disease sepsis is caused by an infection that damages organs. Liver injury, with ferroptosis playing a key role, is an early sign of sepsis. G...
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Ferrostatin-1 alleviates tissue and cell damage in diabetic retinopathy by improving the antioxidant capacity of the Xc--GPX4 system
Diabetic retinopathy (DR) is a common microvascular complication leading to a high blindness rate among patients with diabetes. Ferroptosis is a type...
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Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome
Demand for a cure of liver fibrosis is rising with its increasing morbidity and mortality. Therefore, it is an urgent issue to investigate its...
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Autonomous electrochemical system for ammonia oxidation reaction measurements at the International Space Station
An autonomous electrochemical system prototype for ammonia oxidation reaction (AOR) measurements was efficiently done inside a 4'' x 4'' x 8'' 2U...
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ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–
The amino acid antiporter system Xc − is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect...
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In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma
Interferon-gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein...
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PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma
Effective strategies for hepatocellular carcinoma, which is the second leading cause of death worldwide, remain limited. A growing body of emerging...
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Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases
Ferroptosis is a newly discovered form of cell death that is featured in a wide range of diseases. Exosome therapy is a promising therapeutic option...
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Recent progress in ferroptosis: inducers and inhibitors
Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years,...
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Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
Matrine (MT), an active ingredient derived from Sophor flavescens Ait , is used as a therapeutic agent to treat liver disease and cancer. However, the...
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3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) induces cell death through ferroptosis and acts as a trigger of apoptosis in kidney cells
Ferroptosis is a cell death mechanism characterized by intracellular iron accumulation and lipid peroxidation. Effects of uremic toxins on...
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Double-Barrel Perfusion System for Modification of Luminal Contents of Intestinal Organoids
Organoids are 3D cultures of self-organized adult or pluripotent stem cells with an epithelial membrane enclosing a defined fluid-filled lumen. These...
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Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key...
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Dehydroascorbic acid sensitizes cancer cells to system xc- inhibition-induced ferroptosis by promoting lipid droplet peroxidation
Since the discovery of ferroptosis, it has been postulated that this type of cell death could be utilized in treatments for cancer. Unfortunately,...
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Ferroptosis in Central Nervous System Hypoxia–Ischemia
Millions of people suffer from acute hypoxic–ischemic brain injuries (HIBIs) such as stroke and neonatal HIBI worldwide each year, resulting in...
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High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation
Glioblastoma patients have a poor prognosis mainly due to temozolomide (TMZ) resistance. NRF2 is an important transcript factor involved in...
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Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates...
