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Security check: plant immunity under temperature surveillance
Plant pathogens can damage crops, leading to reduced productivity and threatening global food security. Several strategies have been developed to...
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EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance
Immunotherapies that produce durable responses in some malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to rampant immune...
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Necroptosis stimulates interferon-mediated protective anti-tumor immunity
Necroptosis is an inflammatory form of cell suicide that critically depends on the kinase activity of Receptor Interacting Protein Kinase 3 (RIPK3)....
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Co-evolution of immunity and seasonal influenza viruses
Seasonal influenza viruses cause recurring global epidemics by continually evolving to escape host immunity. The viral constraints and host immune...
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Innate Immunity
Research on the innate immunity has accelerated over the last decades. The main reason for this has been the discovery of receptors recognizing...
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BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking
BRI1-ASSOCIATED KINASE 1 (BAK1/SERK3) and its closest homolog BAK1-LIKE 1 (BKK1/SERK4) are leucine-rich repeat receptor kinases (LRR-RKs) belonging...
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Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and...
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Conventional type 1 dendritic cells (cDC1) in cancer immunity
Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with...
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Macropinocytosis in Phagocyte Function and Immunity
Phagocytes play critical roles in the maintenance of organismal homeostasis and immunity. Central to their role is their ability to take up and...
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The effects of MYC on tumor immunity and immunotherapy
The oncogene MYC is dysregulated in a host of human cancers, and as an important point of convergence in multitudinous oncogenic signaling pathways,...
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STING pathway as a cancer immunotherapy: Progress and challenges in activating anti-tumor immunity
The stimulator of the interferon genes (STING) signaling pathway plays a crucial role in innate immunity by detecting cytoplasmic DNA and initiating...
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Household immunity and individual risk of infection with dengue virus in a prospective, longitudinal cohort study
Although it is known that household infections drive the transmission of dengue virus (DENV), it is unclear how household composition and the immune...
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Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota
Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve therapeutic...
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Combination of tumor antigen drainage and immune activation to promote a cancer-immunity cycle against glioblastoma
While conventional cancer modalities, such as chemotherapy and radiotherapy, act through direct killing of tumor cells, cancer immunotherapy elicits...
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Plant Immunity: A Plastic System Operated Through Cell-Fate Transition
Plants are continuously exposed to pathogen challenges. To defend themselves, plants have developed sophisticated innate and induced immune...
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KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an...
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Evaluation of longitudinal passive immunity transfer against lumpy skin disease virus in calves by different serological methods
To implement effective lumpy skin disease (LSD) control measures, such as timely vaccination, particularly in calves and serological monitoring, it...
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Clinical course and management of COVID-19 in the era of widespread population immunity
The clinical implications of COVID-19 have changed since SARS-CoV-2 first emerged in humans. The current high levels of population immunity, due to...
