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Efficient targeted recombination with CRISPR/Cas9 in hybrids of Caenorhabditis nematodes with suppressed recombination
BackgroundHomology-based recombination (HR) is the cornerstone of genetic map**. However, a lack of sufficient sequence homology or the presence of...
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Molecular mechanisms and regulation of recombination frequency and distribution in plants
Key messageRecent developments in understanding the distribution and distinctive features of recombination hotspots are reviewed and approaches are...
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Fine-scale contemporary recombination variation and its fitness consequences in adaptively diverging stickleback fish
Despite deep evolutionary conservation, recombination rates vary greatly across the genome and among individuals, sexes and populations. Yet the...
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Methylomes as key features for predicting recombination in some plant species
Knowing how chromosome recombination works is essential for plant breeding. It enables the design of crosses between different varieties to combine...
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Physical map** of the wheat genes in low-recombination regions: radiation hybrid map** of the C-locus
Key MessageThis work reports the physical map** of an important gene affecting spike compactness located in a low-recombination region of hexaploid...
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Meiotic recombination dynamics in plants with repeat-based holocentromeres shed light on the primary drivers of crossover patterning
Centromeres strongly affect (epi)genomic architecture and meiotic recombination dynamics, influencing the overall distribution and frequency of...
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RecView: an interactive R application for locating recombination positions using pedigree data
BackgroundRecombination reshuffles alleles at linked loci, allowing genes to evolve independently and consequently enhancing the efficiency of...
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Combined Use of Unidirectional Site-Specific Recombination System and CRISPR-Cas Systems for Plant Genome Editing
Site-specific recombination (SSR) systems have been extensively used for controlled genome modification in eukaryotic cells, especially for DNA...
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ZmSPO11-2 is critical for meiotic recombination in maize
Most plant species have three or more SPO11/TOPOVIA homologs and two TOPOVIB homologs, which associate to trigger meiotic double-strand break (DSB)...
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The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination
The BRCA1/BARD1 complex plays a key role in the repair of DNA double-strand breaks (DSBs) in both somatic cells and germ cells. However, the...
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Meiotic prophase roles of Pds5 in recombination and chromosome condensation in budding yeast
Genetic variation in eukaryotes is mediated during meiosis by the exchange of genetic material between homologous chromosomes to produce recombinant...
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RETRACTED ARTICLE: RAD54L promotes progression of hepatocellular carcinoma via the homologous recombination repair pathway
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence worldwide. The underlying mechanisms remain poorly understood. The DNA...
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BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination
Embryonic stem cells (ESCs) have a significantly lower mutation load compared to somatic cells, but the mechanisms that guard genomic integrity in...
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The recombination regulator RecX negatively regulates heat-stable antifungal factor (HSAF) biosynthesis in Lysobacter enzymogenes
Bacteria often use multiple transcription factors to regulate specific biological processes. Biosynthesis of heat-stable antifungal factor (HSAF) is...
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The fate of a suppressed X-linked meiotic driver: experimental evolution in Drosophila simulans
Sex-ratio (SR) meiotic drivers are X-linked selfish genetic elements that promote their own transmission by preventing the production of Y-bearing...
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RNA 2'-O-methylation promotes persistent R-loop formation and AID-mediated IgH class switch recombination
BackgroundRNA–DNA hybrids or R-loops are associated with deleterious genomic instability and protective immunoglobulin class switch recombination...
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DNA Mutation, Repair, and Recombination
A mutation is a process of alteration in genome sequence by mistakes during DNA replication or as the result of environmental stress including...
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Structural variation and DNA methylation shape the centromere-proximal meiotic crossover landscape in Arabidopsis
BackgroundCentromeres load kinetochore complexes onto chromosomes, which mediate spindle attachment and allow segregation during cell division....
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Insertion orientation within the cassette affects gene-targeting success during ends-out recombination in the yeast Saccharomyces cerevisiae
Gene-targeting is one of the most important molecular tools for genomic manipulations for research and industrial purposes. However, many factors...
