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Extracellular matrices of stromal cell subtypes regulate phenotype and contribute to the stromal microenvironment in vivo
BackgroundBone marrow stromal cells (BMSCs) are highly heterogeneous, which may reflect their diverse biological functions, including tissue...
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Stromal cells in the tumor microenvironment: accomplices of tumor progression?
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells...
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Single-cell analysis reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of ovarian cancer
High-grade serous ovarian carcinoma (HGSOC) is a heterogeneous disease, and a highstromal/desmoplastic tumor microenvironment (TME) is associated...
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Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment
Macrophages and tumour stroma cells account for the main cellular components in the tumour microenvironment (TME). Current advancements in...
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Deciphering the tumor immune microenvironment of imatinib-resistance in advanced gastrointestinal stromal tumors at single-cell resolution
The heterogeneous nature of tumors presents a considerable obstacle in addressing imatinib resistance in advanced cases of gastrointestinal stromal...
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HIF-1α is an important regulator of IL-8 expression in human bone marrow stromal cells under hypoxic microenvironment
The secretion of IL-8 has been found increasing for different reasons in human bone marrow stromal cells (BMSCs), resulting in poor prognosis in...
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A new generation of mesenchymal stromal/stem cells differentially trained by immunoregulatory probiotics in a lupus microenvironment
BackgroundIncreasing evidence suggests that multipotent mesenchymal stem/stromal cells (MSCs) are a promising intervention strategy in treating...
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Osteosarcoma cells exhibit functional interactions with stromal cells, fostering a lung microenvironment conducive to the establishment of metastatic tumor cells
BackgroundOsteosarcoma (OS) stands out as the most common bone tumor, with approximately 20% of the patients receiving a diagnosis of metastatic OS...
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The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers
Typically associated with solid tumors, hypoxia contributes to tumor angiogenesis and lymphangiogenesis through various molecular mechanisms....
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Develo** ovine mammary terminal duct lobular units have a dynamic mucosal and stromal immune microenvironment
The human breast and ovine mammary gland undergo striking levels of postnatal development, leading to formation of terminal duct lobular units...
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Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma
Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with a high probability of metastasis. The tumor microenvironment (TME) plays a...
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Macrophage barrier in the tumor microenvironment and potential clinical applications
The tumor microenvironment (TME) constitutes a complex microenvironment comprising a diverse array of immune cells and stromal components. Within...
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The dynamic tumor–stromal crosstalk: implications of ‘stromal-hot’ tumors in the process of epithelial–mesenchymal transition in breast cancer
Background:Breast cancer metastatic programming involves an intricate process by which the tumor cell coevolves with the surrounding extracellular...
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Molecular Changes in Immunological Characteristics of Bone Marrow Multipotent Mesenchymal Stromal Cells in Lymphoid Neoplasia
AbstractImmune system and bone marrow stromal cells play an important role in maintaining normal hematopoiesis. Lymphoid neoplasia disturbs not only...
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Bioengineered skin constructs based on mesenchymal stromal cells and acellular dermal matrix exposed to inflammatory microenvironment releasing growth factors involved in skin repair
BackgroundSkin tissue engineering is a rapidly evolving field of research that effectively combines stem cells and biological scaffolds to replace...
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MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes
Ineffective hematopoiesis is a hallmark of myelodysplastic syndromes (MDS). Hematopoietic alterations in MDS patients strictly correlate with...
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Cancer Stem Cells Niche Regulation Within the Tumor Microenvironment
Purpose of ReviewSeveral cancer stem cells (CSCs) niches have been identified in the tumor microenvironment. Hence, it is important to review the...
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Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling
The efficient clearance of dead and dying cells, efferocytosis, is critical to maintain tissue homeostasis. In the bone marrow microenvironment...
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Mesenchymal stem/stromal cells from human pluripotent stem cell-derived brain organoid enhance the ex vivo expansion and maintenance of hematopoietic stem/progenitor cells
BackgroundMesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic...
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Epigenetic Regulation in Breast Cancer Tumor Microenvironment
Breast cancer is an exceedingly complex disease that is driven by multiple factors and aberrantly regulated pathways. Mounting evidence suggests that...