Search
Search Results
-
The unusual gene architecture of polyubiquitin is created by dual-specific splice sites
BackgroundThe removal of introns occurs through the splicing of a 5′ splice site (5′ss) with a 3′ splice site (3′ss). These two elements are...
-
A rare non-canonical splice site in Trema orientalis SYMRK does not affect its dual symbiotic functioning in endomycorrhiza and rhizobium nodulation
BackgroundNitrogen-fixing nodules occur in ten related taxonomic lineages interspersed with lineages of non-nodulating plant species. Nodules result...
-
The Hedgehog pathway in penaeid shrimp: developmental expression and evolution of splice junctions in Pancrustacea
Penaeid shrimp embryos undergo holoblastic division, gastrulation by invagination, and hatching as a nauplius larva. Posterior segments form and...
-
Splice-disrupt genomic variants in prostate cancer
BackgroundSplice-disrupt genomic variants are one of the causes of cancer-causing errors in gene expression. Little is known about splice-disrupt...
-
Map** intron retention events contributing to complex traits using splice quantitative trait locus
BackgroundAlternative splicing (AS) of mRNA plays an important roles in transcriptome diversity, involving regulation of plant growth and stress...
-
Arresting Spliceosome Intermediates at Various Stages of the Splicing Pathway
The spliceosome is a dynamic ribonucleoprotein particle and is assembled via sequential binding of five snRNAs and numerous protein factors. To...
-
The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway....
-
SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency
BackgroundIntrons are generally removed from primary transcripts to form mature RNA molecules in a post-transcriptional process called splicing. An...
-
Voltage-Gated Calcium Channels in the Afferent Pain Pathway
Voltage-gated calcium channelsVoltage-gated calcium channels (VGCCs) are important mediators of signal transduction in the primary afferent painPains...
-
Exact transcript quantification over splice graphs
BackgroundThe probability of sequencing a set of RNA-seq reads can be directly modeled using the abundances of splice junctions in splice graphs...
-
Analysis of CCR2 splice variant expression patterns and functional properties
BackgroundC–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells,...
-
Nonsense-mediated mRNA decay pathway in plants under stress: general gene regulatory mechanism and advances
Main conclusionNonsense-mediated mRNA decay in eukaryotes is vital to cellular homeostasis. Further knowledge of its putative role in plant RNA...
-
OCC-1D regulates Wnt signaling pathway: potential role of long noncoding RNA in colorectal cancer
BackgroundAberrant activation of the Wnt signaling pathway is observed in most colorectal cancers (CRC). OCC-1D is a splice variant of OCC-1 gene...
-
Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway
Drp1 (Dynamin-Related Protein 1) is a cytoplasmic GTPase protein encoded by the DNM1L gene that influences mitochondrial dynamics by mediating...
-
GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
G protein-coupled receptor 56 (GPR56/ADGRG1) is a multifunctional adhesion GPCR involved in diverse biological processes ranging from development to...
-
LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway
LAMB3, a major extracellular matrix and basal membrane component, is involved in wound healing. We aimed to understand its role in Asherman’s...
-
A network map of GDNF/RET signaling pathway in physiological and pathological conditions
Glial cell line-derived neurotrophic factor (GDNF) signals through a multi-component receptor system predominantly consisting of...
-
The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signaling
Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor...
-
Targeting the hedgehog pathway in MET mutation cancers and its effects on cells associated with cancer development
The mutation of MET plays a crucial role in the initiation of cancer, while the Hedgehog (Hh) pathway also plays a significant role in cell...
-
In Vivo Tissue-Specific Knockdown of circRNAs Using shRNAs in Drosophila melanogaster
Studying circular RNAs’ function in vivo has been challenging due to the lack of generic tools to manipulate their levels without affecting their...