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1,3-Dipolar cycloaddition reactions of isatin-derived azomethine ylides for the synthesis of spirooxindole and indole-derived scaffolds: recent developments
The unique therapeutic and biological characteristics of spirooxindole have led to the presentation of numerous reactions for the synthesis of...
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Anticonvulsant activity, molecular modeling and synthesis of spirooxindole-4H-pyran derivatives using a novel reusable organocatalyst
Fifteen derivatives of spirooxindole-4 H -pyran (
A 1 –A 15 ) were subjected to evaluate through intravenous infusion of pentylenetetrazole (PTZ)-induced...
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Investigation of spirooxindole-pyrrolidine derivatives as acetylcholinesterase inhibitors using molecular docking/dynamics simulations, bioisosteric replacement, MEP, and ADME/Tox properties
Acetylcholinesterase is used as a key target in the treatment of Alzheimer's disease. Recently, a series of new spirooxindolepyrrolidine derivatives...
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Synthesis of mono- and bis-spirooxindole derivatives “on water” using double salt of aluminum sulfate–sulfuric acid as a reusable catalyst
AbstractThe preparation of double salt of aluminum sulfate–sulfuric acid (Al 4 (SO 4 ) 6 ·(H 2 SO 4 )·24H 2 O) by the reaction of aluminum sulfate and sulfuric...
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Design and synthesis of novel spirooxindole–indenoquinoxaline derivatives as novel tryptophanyl-tRNA synthetase inhibitors
AbstractIn the current study, we used an integrated approach combining bioinformatics, rational drug design, one-pot synthesis, and biological...
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Asymmetric synthesis of spiro[4H-chromene-3,3′-oxindoles] via a squaramide-organocatalytic three-component cascade Knoevenagel/Michael/cyclization sequence
Asymmetric synthesis of spiro[4 H -chromene-3,3′-oxindole] derivatives was realized through an organocatalytic cascade Knoevenagel/Michael/cyclization...
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Recent developments in green approaches for sustainable synthesis of indole-derived scaffolds
An important issue to discover biological structures is the design of sustainable, safe, clean, cost-effective, excellent efficient synthetic...
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Design and synthesis of novel quinazolinyl-bisspirooxindoles as potent anti-tubercular agents: an ultrasound-promoted methodology
AbstractThe essential need for the potent anti-tubercular (anti-TB) agents with high selectivity and safety profile prompted us to synthesize a new...
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Citrinadin C, a new cytotoxic pentacyclic alkaloid from marine-derived fungus Penicillium citrinum
A new cytotoxic pentacyclic alkaloid, citrinadin C ( 1 ), together with four known compounds ( 2 – 5 ), were isolated from deep-sea-derived fungus Penicilliu...
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A one-pot synthesis of piperidinium spirooxindoline-pyridineolates and indole-substituted pyridones in aqueous or ethanol medium
Piperidinium spirooxindoline-pyridineolate has been prepared via one-pot multicomponent reaction of isatin, malononitrile, cyanoacetohydrazide, and...
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Structural basis for NaV1.7 inhibition by pore blockers
Voltage-gated sodium channel Na V 1.7 plays essential roles in pain and odor perception. Na V 1.7 variants cause pain disorders. Accordingly, Na V 1.7 has...
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Formation of bis-spiropyrrolidines from isatin, secondary amines, and alkylidene Meldrum’s acids
A catalyst-free synthesis of stable bis-spiropyrrolidines from isatin, secondary amines, and alkylidene Meldrum’s acids in MeCN in 75–95% yield is...
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Emerging functions within the enzyme families of plant alkaloid biosynthesis
The alkaloids are a major class of nitrogen-containing plant specialized metabolites that function as both toxic defense compounds and useful...
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A Green one-pot three component synthesis of thiazolidine-2,4-dione based bisspirooxindolo-pyrrolidines with [Bmim]BF4: their in vitro and in silico anti-TB studies
A simple and effective three-component one-pot green methodology was employed for the synthesis of a new thiazolidine-2,4-dione based...
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Montmorillonite clay-based heterogenous catalyst for the synthesis of nitrogen heterocycle organic moieties: a review
The use of montmorillonite clay as solid catalyst has grabbed much attention in the liquid phase reactions for organic synthesis. In recent years,...
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Drug Design Methods to Regulate Protein–Protein Interactions
Inhibiting anomalous protein–protein interactions has led to the discovery of drugs (small molecules, precisely) that can inhibit such interactions...
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Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization
AbstractA highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important...
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Small-Molecule Inhibitors of Protein–Protein Interactions as Therapeutics
Protein–protein interactions (PPIs) have been sought as putative therapeutic targets for the advancement of various new treatments. This chapter...
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Industrial Applications of Green Solvents in Organic and Drug Synthesis for Sustainable Development of Chemical Process and Technologies
Sustainable and/or green chemistry has become an avenue that provides ways of develo** an efficient complex chemical synthesis of structural...
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A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions
A catalyst-free green methodology for the synthesis of pharmacologically important spirooxindole derivatives has been developed by a three-component...
