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Revealing the single-channel characteristics of OprD (OccAB1) porins from hospital strains of Acinetobacter baumannii
Nowadays, reports of antimicrobial resistance (AMR) against many antibiotics are increasing because of their misapplication. With this rise, there is...
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Fabrication of electron tunneling probes for measuring single-protein conductance
Studying the electrical properties of individual proteins is a prominent research area in the field of bioelectronics. Electron tunnelling or quantum...
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Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. Structural analysis of CFTR...
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Regulation of Single-Channel Conductance of Voltage-Dependent Anion Channel by Mercuric Chloride in a Planar Lipid Bilayer
The existence of mercury in various forms, e.g., elemental, organic, and inorganic has been known for decades. In any of these forms, it is poisonous...
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CO2 mesophyll conductance regulated by light: a review
Main ConclusionLight quality and intensity regulate plant mesophyll conductance, which has played an essential role in photosynthesis by controlling...
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Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants
Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain...
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Molecular dynamics study of Cl− permeation through cystic fibrosis transmembrane conductance regulator (CFTR)
The recent elucidation of atomistic structures of Cl − channel CFTR provides opportunities for understanding the molecular basis of cystic fibrosis....
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Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology
Aquaporins (AQPs) are multifunctional transmembrane channel proteins permeable to water and an expanding array of solutes. AQP-mediated ion channel...
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Major vacuolar TPC1 channel in stress signaling: what matters, K+, Ca2+ conductance or an ion-flux independent mechanism?
Two-pore cation channel, TPC1, is ubiquitous in the vacuolar membrane of terrestrial plants and mediates the long distance signaling upon biotic and...
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Extracellular Signal-Regulated Kinase1 (ERK1)-Mediated Phosphorylation of Voltage-Dependent Anion Channel (VDAC) Suppresses its Conductance
ERK1 is one of the members of the mitogen-activated protein kinases that regulate important cellular functions. VDAC is located at the outer membrane...
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Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance
Positively charged amino acid side-chains play important roles in anion binding and permeation through the CFTR chloride channel. One pore-lining...
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Towards understanding single-channel characteristics of OccK8 purified from Pseudomonas aeruginosa
Antibiotic resistance in Gram-negative bacteria causes serious health issues worldwide. Bacteria employ several resistance mechanisms to cope with...
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Esc peptides as novel potentiators of defective cystic fibrosis transmembrane conductance regulator: an unprecedented property of antimicrobial peptides
Mutations in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein lead to persistent lung bacterial infections, mainly due to Ps...
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Electrophysiology of Ctenophore Smooth Muscle
Unlike in the Cnidaria, where muscle cells are coupled together into an epithelium, ctenophore muscles are single, elongated, intramesogleal...
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Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells
BackgroundPhysical exercise directly stretching the peripheral nerve promotes nerve regeneration; however, its action mechanism remains elusive. Our...
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Long-term memory in Staphylococcus aureus α-hemolysin ion channel kinetics
The kinetics of an ion channel are classically understood as a random process. However, studies have shown that in complex ion channels, formed by...
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Local Mechano-Dependent Calcium Influx Controls the Activity of Calcium-Dependent Potassium Channels of Big and Small Conductance in Human Lymphoma Cells
AbstractBurkitt’s lymphoma is an aggressive and fast-growing form of non-Hodgkin’s lymphoma with the highest invasive potential of all types of...
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Effect of Large-Conductance Calcium-Dependent K+ Channel Activator NS1619 on Function of Mitochondria in the Heart of Dystrophin-Deficient Mice
AbstractDystrophin-deficient muscular dystrophy (Duchenne dystrophy) is characterized by impaired ion homeostasis, in which mitochondria play an...
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Asymmetric Lipid Bilayers and Potassium Channels Embedded Therein in the Contact Bubble Bilayer
Cell membranes are highly intricate systems comprising numerous lipid species and membrane proteins, where channel proteins, lipid molecules, and...