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Recurrent neo-sex chromosome evolution in kiwifruit
Sex chromosome evolution is thought to be tightly associated with the acquisition and maintenance of sexual dimorphisms. Plant sex chromosomes have...
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Y chromosome toxicity does not contribute to sex-specific differences in longevity
While sex chromosomes carry sex-determining genes, they also often differ from autosomes in size and composition, consisting mainly of silenced...
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Sex-chromosome mechanisms in cardiac development and disease
Many human diseases, including cardiovascular disease, show differences between men and women in pathology and treatment outcomes. In the case of...
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Generation of iPSC Cell Lines from Patients with Sex Chromosome Aneuploidies
Somatic cell reprogramming allows the generation of human induced pluripotent stem cells (iPSCs) from patient’s cells. The derived iPSCs provide an...
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Dosage compensation of Z sex chromosome genes in avian fibroblast cells
In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole...
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Positive predictive value of noninvasive prenatal testing for sex chromosome abnormalities
BackgroundEarly and intermediate serological screening cannot detect sex chromosome abnormalities. Currently, noninvasive prenatal testing (NIPT) is...
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A chromosome-level genome assembly of Hong Kong catfish (Clarias fuscus) uncovers a sex-determining region
BackgroundHong Kong catfish ( Clarias fuscus ) is an ecologically and economically important species that is widely distributed in freshwater regions...
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Genetic variation in the Y chromosome and sex-biased DNA methylation in somatic cells in the mouse
Several lines of evidence suggest that the presence of the Y chromosome influences DNA methylation of autosomal loci. To better understand the impact...
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Sex-Linked Inheritance
Sexual differentiation in animals is given by a pair of chromosomes, called sex chromosomes. These are the chromosomes that will define whether an...
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Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci
Homomorphic sex chromosomes and their turnover are common in teleosts. We investigated the evolution of nascent sex chromosomes in several...
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Comparative Genomics of Sex, Chromosomes, and Sex Chromosomes in Caenorhabditis elegans and Other Nematodes
The nematode phylum has evolved a remarkable diversity of reproductive modes, including the repeated emergence of asexuality and hermaphroditism...
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Massive expansion of sex-specific SNPs, transposon-related elements, and neocentromere formation shape the young W-chromosome from the mosquitofish Gambusia affinis
BackgroundThe Western mosquitofish, Gambusia affinis , is a model for sex chromosome organization and evolution of female heterogamety. We previously...
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Application of the prenatal BACs-on-Beads™ assay for rapid prenatal detection of sex chromosome mosaicism
The prenatal BACs-on-Beads™ (BoBs) assay was introduced for rapid detection of abnormalities of chromosomes 13, 18, 21, X, and Y and specific nine...
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Y chromosome is moving out of sex determination shadow
Although sex hormones play a key role in sex differences in susceptibility, severity, outcomes, and response to therapy of different diseases, sex...
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Evaluation of four methods to identify the homozygotic sex chromosome in small populations
BackgroundWhole genomes are commonly assembled into a collection of scaffolds and often lack annotations of autosomes, sex chromosomes, and organelle...
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Mendel’s Principles of Inheritance and the Chromosome Theory
Inheritance is a fundamental feature of all organisms. A critical question is how our genes and traits are transmitted to the next generations. In...
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Chromosome-scale assemblies of the male and female Populus euphratica genomes reveal the molecular basis of sex determination and sexual dimorphism
Reference-quality genomes of both sexes are essential for studying sex determination and sex-chromosome evolution, as their gene contents and...
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Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation
Contrary to classic theory prediction, sex-chromosome homomorphy is prevalent in the animal kingdom but it is unclear how ancient homomorphic sex...
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DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy
BackgroundSex is an important covariate of epigenome-wide association studies due to its strong influence on DNA methylation patterns across numerous...
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The spinach YY genome reveals sex chromosome evolution, domestication, and introgression history of the species
BackgroundSpinach ( Spinacia oleracea L.) is a dioecious species with an XY sex chromosome system, but its Y chromosome has not been fully...
