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Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum
Extracellular vesicles (EVs) are important players in melanoma progression, but their use as clinical biomarkers has been limited by the difficulty...
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Prognostic biomarker discovery based on proteome landscape of Chinese lung adenocarcinoma
Despite recent innovations in imaging and genomic screening promotes advance in diagnosis and treatment of lung adenocarcinoma (LUAD), there remains...
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Mass-spectrometric analysis of APOB polymorphism rs1042031 (G/T) and its influence on serum proteome of coronary artery disease patients: genetic-derived proteomics consequences
Genetic polymorphisms of apolipoprotein B gene ( APOB) may result into serum proteomic perturbance in Coronary Artery Disease (CAD). The current...
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Frontiers in plasma proteome profiling platforms: innovations and applications
Biomarkers play a crucial role in advancing precision medicine by enabling more targeted and individualized approaches to diagnosis and treatment....
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Assessing the Phagosome Proteome by Quantitative Mass Spectrometry
The process of phagocytosis involves a series of defined steps, including the formation of a new intracellular organelle, i.e., the phagosome, and...
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Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation
Engagement of the T cell receptor (TCR) triggers molecular reprogramming leading to the acquisition of specialized effector functions by CD4 helper...
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Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome
BackgroundHuman induced pluripotent stem cells (hiPSCs) and their differentiated cell types have a great potential for tissue repair and...
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Cell membrane proteome analysis in HEK293T cells challenged with α-synuclein amyloids
Amyloids interact with plasma membranes. Extracellular amyloids cross the plasma membrane barrier. Internalized extracellular amyloids are reported...
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Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
BackgroundThe oocyte-to-embryo transition (OET) converts terminally differentiated gametes into a totipotent embryo and is critically controlled by...
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New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia
Plasma-derived therapeutic proteins are produced through an industrial fractionation process where proteins are purified from individual...
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In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease
Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Monitoring the early diagnostic period and...
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Identification and validation of serum autoantibodies in children with B-cell acute lymphoblastic leukemia by serological proteome analysis
BackgroundB-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood. Even though significant progresses have been made...
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Proteome-scale tagging and functional screening in mammalian cells by ORFtag
The systematic determination of protein function is a key goal of modern biology, but remains challenging with current approaches. Here we present...
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Proteome alterations during clonal isolation of established human pancreatic cancer cell lines
Clonal isolation is an integral step of numerous workflows in genome editing and cell engineering. It comprises the isolation of a single progenitor...
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sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
BackgroundCell surface proteins perform critical functions related to immune response, signal transduction, cell–cell interactions, and cell...
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The ionome and proteome landscape of aging in laying hens and relation to egg white quality
The ionome is essential for maintaining body function and health status by participating in diverse key biological processes. Nevertheless, the...
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Robust optimization of SWATH-MS workflow for human blood serum proteome analysis using a quality by design approach
BackgroundIt is not enough to optimize proteomics assays. It is critical those assays are robust to operating conditions. Without robust assays,...
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Mass spectrometry-based draft of the mouse proteome
The laboratory mouse ranks among the most important experimental systems for biomedical research and molecular reference maps of such models are...
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Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Glioblastoma is one of the most malignant primary brain cancer. Despite surgical resection with modern technology followed by chemo-radiation therapy...
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On the Feasibility of Using an Ultra-Fast DirectMS1 Method of Proteome-Wide Analysis for Searching Drug Targets in Chemical Proteomics
AbstractProtein quantitation in tissue cells or physiological fluids based on liquid chromatography/mass spectrometry is one of the key sources of...
