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Human embryonic stem cell-specific role of YAP in maintenance of self-renewal and survival
Human embryonic stem cells (hESCs) have unique characteristics, such as self-renewal and pluripotency, which are distinct from those of other cell...
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The involvement of bioactive factors in the self-renewal and stemness maintenance of spermatogonial stem cells
Spermatogenesis is usually accompanied throughout mammalian lifetime, transmitting genetic information to the next generation, which is mainly...
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RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
Purpose of ReviewThe maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of...
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Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling
Intestinal stem cells (ISCs) play a crucial role in the continuous self-renewal and recovery of the intestinal epithelium. In previous studies, we...
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Specific downregulation of microRNA-186 induces neural stem cell self-renewal by upregulating Bmi-1/FoxG1 expression
Self-renewal and differentiation in neural stem cells (NSCs) are modulated by microRNAs (miRNAs). However, the recent evidence available is not...
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The long noncoding RNA TINCR promotes self-renewal of human liver cancer stem cells through autophagy activation
Hepatocellular carcinoma (HCC) is an extraordinarily heterogeneous tumor, which holds high recurrence and metastasis rates. Liver cancer stem cells...
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Regulation Mechanisms and Maintenance Strategies of Stemness in Mesenchymal Stem Cells
Stemness pertains to the intrinsic ability of mesenchymal stem cells (MSCs) to undergo self-renewal and differentiate into multiple lineages, while...
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Ubiquitin-Proteasome System in the Regulation of Cell Pluripotency and Differentiation
AbstractEmbryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) demonstrate unique abilities for continuous self-renewal and...
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MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro
The involvement of microRNAs (miRNAs) in orchestrating self-renewal and differentiation of stem cells has been revealed in a number of recent...
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Principles of Variety Maintenance for Quality Seed Production
Development of new plant varieties is key to sustainable agriculture, specially given that climate change poses newer challenges with uncertainties...
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Targeting LGSN restores sensitivity to chemotherapy in gastric cancer stem cells by triggering pyroptosis
Gastric cancer (GC) is notoriously resistant to current therapies due to tumor heterogeneity. Cancer stem cells (CSCs) possess infinite self-renewal...
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The spatiotemporal heterogeneity of the biophysical microenvironment during hematopoietic stem cell development: from embryo to adult
Hematopoietic stem cells (HSCs) with the ability to self-renew and differentiate are responsible for maintaining the supply of all types of blood...
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Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial tumor suppressor gene identified to possess phosphatase...
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Forkhead box O proteins: steering the course of stem cell fate
Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately...
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Cancer stem cells: advances in the glucose, lipid and amino acid metabolism
Cancer stem cells (CSCs) are a class of cells with self-renewal and multi-directional differentiation potential, which are present in most tumors,...
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Culture and expansion of murine proximal airway basal stem cells
BackgroundThe stem cell characteristic makes basal cells desirable for ex vivo modeling of airway diseases. However, to date, approaches allowing...
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Rhox6 regulates the expression of distinct target genes to mediate mouse PGCLC formation and ESC self-renewal
BackgroundMouse embryonic stem cells (mESCs) not only retain the property of self-renewal but also have the ability to develop into primordial germ...
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NUP98 and RAE1 sustain progenitor function through HDAC-dependent chromatin targeting to escape from nucleolar localization
Self-renewing somatic tissues rely on progenitors to support the continuous tissue regeneration. The gene regulatory network maintaining progenitor...
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METTL3 knockdown promotes temozolomide sensitivity of glioma stem cells via decreasing MGMT and APNG mRNA stability
Chemo-resistance hinders the therapeutic efficacy of temozolomide (TMZ) in treating glioblastoma multiforme (GBM). Recurrence of GBM even after...
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Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression
BackgroundSpermatogonial stem cells (SSCs) provide a foundation for robust and continual spermatogenesis in mammals. SSCs self-renew to maintain a...
