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The cerebellum contributes to generalized seizures by altering activity in the ventral posteromedial nucleus
Thalamo-cortical networks are central to seizures, yet it is unclear how these circuits initiate seizures. We test whether a facial region of the...
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Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy
BackgroundEpilepsy affects ∼60 million people worldwide. Most antiseizure medications in the market act on voltage-gated sodium or calcium channels,...
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Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis
Childhood febrile seizures (FS) represent one of the most common types of seizures and may lead to severe neurological damage and an increased risk...
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Chronic Dysregulation of Glutamatergic Transmission in the Hippocampus of Krushinsky–Molodkina Rats Induced by Repeated Epileptiform Seizures
AbstractTemporal lobe epilepsy is characterized by the development of associated neurological and psychiatric disorders. Obviously, one of the...
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Illegal trade of pangolins in India with international trade links: an analysis of seizures from 1991 to 2022
Pangolins have become one of the most intensely poached and trafficked mammal species, exploited mainly for the food and traditional medicine trade....
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Anticonvulsant Efficacy of Inhibition of Synaptic and Extrasynaptic GABA-Transporters in the Prevention of Hyperbaric Oxygen Seizures
AbstractHyperbaric oxygen (HBO 2 ) inhibits GABAergic neurotransmission in the brain, which can lead to the development of seizure disorders known as...
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Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice
The underlying etiologies of seizures are highly heterogeneous and remain incompletely understood. While studying the unfolded protein response (UPR)...
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Analysis of the Functional State of Astroglia in the Hippocampus of Rats Genetically Prone to Audiogenic Seizures
AbstractIt was shown that abnormalities in astrocyte functions can cause alterations in neuronal excitability and promote the development of...
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Clinical Characteristics of Seizures and Epilepsy after Ischaemic Stroke
Abstract —Ischaemic stroke (IS) is a frequent cause of epilepsy.The aim of the study was to clarify the clinical features of post-stroke epilepsy...
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Involvement of Glutamine Synthetase in the Development of Hyperbaric Oxygen Seizures
AbstractHyperbaric oxygen (HBO 2 ) causes a toxic effect on the central nervous system via poorly understood mechanisms. The aim of this study was to...
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Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures
The electrographic manifestation of neural activity can reflect the relationship between the faster action potentials of individual neurons and the...
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The LGI1 protein: molecular structure, physiological functions and disruption-related seizures
Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly expressed in the brain, and involved in central nervous system...
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Molecular characterization of de novo ring chromosome 21 in a child with seizures, growth retardation, and multiple congenital anomalies
The ring chromosome 21[r(21)] syndrome is a rare disorder, and mainly occurs as a de novo event. However, a wide variation of the phenotype has been...
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Syntabulin regulates neuronal excitation/inhibition balance and epileptic seizures by transporting syntaxin 1B
Epilepsy is a widespread neurological disorder affecting more than 65 million people, but the mechanisms of epilepsy remains unknown. Abnormal...
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Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity
Although many studies have explored the mechanism of epilepsy, it remains unclear and deserves further investigation. Vezatin has been reported to be...
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Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR antibody) encephalitis, a distinct neuro-immunological disorder in...
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Biochemical Assessments of Neurotrophin-3 and Zinc Involvement in the Pathophysiology of Pediatric Febrile Seizures
Febrile seizures (FSs) are a common occurrence in young children and a serious concern in pediatric practice; nevertheless, the causes and mechanisms...
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Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
Mutations in the GABRG2 gene encoding the γ-aminobutyric acid (GABA) A receptor gamma 2 subunit are associated with genetic epilepsy with febrile...
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SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
Aberrantly synchronized neuronal discharges in the brain lead to epilepsy, a devastating neurological disease whose pathogenesis and mechanism are...
