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Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth
Solute Carrier Family 3, Member 2 (SLC3A2 or 4F2hc) is a multifunctional glycoprotein that mediates integrin-dependent signaling, acts as a...
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m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
3-Methylcholanthracene (3-MC) is one of the most carcinogenic polycyclic aromatic hydrocarbons (PAHs). Long-term exposure to PAHs has been thought of...
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Identification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencing
BackgroundThe pathogenesis of vitiligo remains unclear. The genes encoding vitiligo-related RNA-binding proteins (RBPs) and their underlying...
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SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway
ObjectiveThis study aimed to explore the mRNA and protein expression of SLC3A2 in laryngeal carcinoma cells and tissues, and functional regulatory...
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Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer
Estrogen receptor (ER) positive breast cancer represents 75% of all breast cancers in women. Although patients with ER+ cancers receive endocrine...
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HCMV-miR-US33-5p promotes apoptosis of aortic vascular smooth muscle cells by targeting EPAS1/SLC3A2 pathway
BackgroundIn patients with acute aortic dissection (AAD), increased vascular smooth muscle cell (VSMC) apoptosis has been found. Human...
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Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells
More than one-third of the world’s population is exposed to Plasmodium vivax malaria, mainly in Asia
1 . P. vivax preferentially invades reticulocytes...
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Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains a highly fatal malignancy partially due to the acquired alterations related to aberrant protein...
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sBioSITe enables sensitive identification of the cell surface proteome through direct enrichment of biotinylated peptides
BackgroundCell surface proteins perform critical functions related to immune response, signal transduction, cell–cell interactions, and cell...
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Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease
Nephrolithiasis is highly prevalent and associated with the increased risk of kidney cancer. The tumor suppressor von Hippel-Lindau (VHL) is critical...
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Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but...
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Amino Acids Transport as an Index of Cancer Stem Cells Dysregulation
The appearance, proliferation, metastasis, and even resistance to chemotherapy depend on the molecular identity of the so-called Cancer Stem Cells...
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1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature
Uveal melanoma (UM) is an ocular cancer, with propensity for lethal liver metastases. When metastatic UM (MUM) occurs, as few as 8% of patients...
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GPR116 promotes ferroptosis in sepsis-induced liver injury by suppressing system Xc–/GSH/GPX4
The disease sepsis is caused by an infection that damages organs. Liver injury, with ferroptosis playing a key role, is an early sign of sepsis. G...
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Nrf2 suppresses erastin-induced ferroptosis through activating system Xc(-) in ovarian cancer
BackgroundOvarian cancer (OV) is a gynecologic tumor with high mortality due to its drug resistance. In most cases, simple standard care is not...
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Genome-wide differential expression profiling of long non-coding RNAs in FOXA2 knockout iPSC-derived pancreatic cells
BackgroundOur recent studies have demonstrated the crucial involvement of FOXA2 in the development of human pancreas. Reduction of FOXA2 expression...
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Ferroptosis in Central Nervous System Hypoxia–Ischemia
Millions of people suffer from acute hypoxic–ischemic brain injuries (HIBIs) such as stroke and neonatal HIBI worldwide each year, resulting in...
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Ferrostatin-1 alleviates tissue and cell damage in diabetic retinopathy by improving the antioxidant capacity of the Xc--GPX4 system
Diabetic retinopathy (DR) is a common microvascular complication leading to a high blindness rate among patients with diabetes. Ferroptosis is a type...
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Ferroptosis: a critical mechanism of N6-methyladenosine modification involved in carcinogenesis and tumor progression
Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid peroxidation. It occurs when multiple redox-active...
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Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming
Metabolic reprogramming is one of the main characteristics of cancer cells and plays pivotal role in the proliferation and survival of cancer cells....
