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10 Sphingosine-1-phosphate metabolism in mammalian cell signalling
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite implicated in the regulation of vital biological processes. Ample evidence...
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Abscisic acid signalling
Signalling of abscisic acid (ABA) in plants is characterized by an amazing number of secondary messengers that are part of the pathway or modulate...
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Redox regulation of UPR signalling and mitochondrial ER contact sites
Mitochondria and the endoplasmic reticulum (ER) have a synergistic relationship and are key regulatory hubs in maintaining cell homeostasis....
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The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos
The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations of purines and...
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A comprehensive multiomics approach reveals that high levels of sphingolipids in cardiac cachexia adipose tissue are associated with inflammatory and fibrotic changes
Cardiac cachexia is a deadly consequence of advanced heart failure that is characterised by the dysregulation of adipose tissue homeostasis. Once...
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Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis
Vascular endothelial growth factor receptor type 2 (VEGFR2, also known as KDR and FLK1) signalling in endothelial cells (ECs) is essential for...
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Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions
Protein Spinster homolog 2 (Spns2) is a sphingosine-1-phosphate (S1P) transporter that releases S1P to regulate lymphocyte egress and trafficking....
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Regulation of cellular and systemic sphingolipid homeostasis
One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual “Sphinx-like” lipids from the brain. Today, we know that...
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S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression
Angiogenesis is a fundamental process underlying the occurrence, growth and metastasis of hepatocellular carcinoma (HCC), a prevalent tumour type...
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The Lysophosphatidylserines—An Emerging Class of Signalling Lysophospholipids
Lysophospholipids are potent hormone-like signalling biological lipids that regulate many important biological processes in mammals (including...
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Protective role of epigallocatechin-3-gallate in NADPH oxidase-MMP2-Spm-Cer-S1P signalling axis mediated ET-1 induced pulmonary artery smooth muscle cell proliferation
The signalling pathway involving MMP-2 and sphingosine-1-phosphate (S1P) in endothelin-1 (ET-1) induced pulmonary artery smooth muscle cell (PASMC)...
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Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia
Haematopoiesis within the bone marrow (BM) represents a complex and dynamic process intricately regulated by neural signaling pathways. This delicate...
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Differences in lipid metabolism in acquired versus preexisting glucose intolerance during gestation: role of free fatty acids and sphingosine-1-phosphate
BackgroundThe prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. There is increasing evidence that GDM is a heterogeneous...
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Anthracycline-induced cardiotoxicity: targeting high-density lipoproteins to limit the damage?
Doxorubicin (DOX) is an anthracycline antibiotic frequently used against a wide range of cancers, including breast cancer. Although the drug is...
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11 Plant sphingolipids
Plants contain a multiplicity of sphingolipid metabolites, such as long-chain bases, long-chain base phosphates, ceramides, glycosylceramides,...
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Life, death and resurrection of plant GPCRs
The activation of G-protein coupled receptors (GPCRs) by extracellular ligands constitutes the first step of heterotrimeric G-protein signalling in...
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Physiological and pathological roles of lipogenesis
Lipids are essential metabolites, which function as energy sources, structural components and signalling mediators. Most cells are able to convert...
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Genomic attributes of airway commensal bacteria and mucosa
Microbial communities at the airway mucosal barrier are conserved and highly ordered, in likelihood reflecting co-evolution with human host factors....
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Prognostic potential of lipid profiling in cancer patients: a systematic review of mass spectrometry-based studies
Cancer prognosis remains a critical clinical challenge. Lipidomic analysis via mass spectrometry (MS) offers the potential for objective prognostic...
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Update of cellular responses to the efferocytosis of necroptosis and pyroptosis
Cell death is a basic physiological process that occurs in all living organisms. A few key players in these mechanisms, as well as various forms of...
