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Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity
Monkeypox was declared a global health emergency by the World Health Organization, and as of March 2023, 86,000 confirmed cases and 111 deaths across...
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DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response
Effective and safe vaccines are invaluable tools in the arsenal to fight infectious diseases. The rapid spreading of severe acute respiratory...
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Adaptive Immune Response Investigation in Lyme Borreliosis
To diagnose Lyme Borreliosis, it is advised to use an enzyme-linked immunosorbent test to check for serum antibodies specific for Lyme and all tests...
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Clinical manifestations and immune response to tuberculosis
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death worldwide caused by a single infectious agent; 1.6...
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Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response
Cancer is an evolutionary process shaped by selective pressure from the microenvironments. However, recent studies reveal that certain tumors undergo...
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HIHISIV: a database of gene expression in HIV and SIV host immune response
In the battle of the host against lentiviral pathogenesis, the immune response is crucial. However, several questions remain unanswered about the...
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Immunomodulation and Humoral Immune Response in Teleost Immunized with Aeromonas-Derived Antigenic Extracellular Bioactive Molecules
The common use of antimicrobials in food-animal production can lead to drug residues in edible tissues for consumers. However, immunomodulators...
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A robust immune-related gene pairs signature for predicting the overall survival of esophageal cancer
BackgroundIdentifying reliable biomarkers could effectively predict esophagus carcinoma (EC) patients with poor prognosis. In this work, we...
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Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targets
The COVID-19 pandemic, caused by the β-coronavirus (β-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to cause...
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Recognition of nonself is necessary to activate Drosophila’s immune response against an insect parasite
BackgroundInnate immune responses can be activated by pathogen-associated molecular patterns (PAMPs), danger signals released by damaged tissues, or...
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Punch-excised explants of bovine mammary gland to model early immune response to infection
BackgroundMammary gland (MG) infections (mastitis) are frequent diseases of dairy cows that affect milk quality, animal welfare and farming...
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A comprehensive analysis of immune features and construction of an immune gene diagnostic model for sepsis
Sepsis is a life-threatening syndrome resulting from immune system dysfunction that is caused by infection. It is of great importance to analyze the...
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Jasmonic Acid (JA) in Plant Immune Response: Unravelling Complex Molecular Mechanisms and Networking of Defence Signalling Against Pathogens
AbstractJasmonic acid (JA) and its derived compound ‘jasmonates’ are a class of potent phytohormones that play pivotal roles in plants’...
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Host Plant Effects on the Caterpillar Immune Response
Given the barrage of natural enemies that lepidopterans face during their larval stage, the immune response should provide reliable, effective...
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Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model
BackgroundTo describe an oncolytic adenovirus (OAd) encoding SP-SA-E7-4-1BBL that is capable of inducing tumor regression in therapeutic assays....
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Trannscriptomics and Immune Response in Human Cancer
Transcriptomic profiling is now used in diverse areas of cancer research, including tumor diagnosis, biomarker discovery, investigating cancer...
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Immune response in COVID-19: what is next?
The coronavirus disease 2019 (COVID-19) has been a global pandemic for more than 2 years and it still impacts our daily lifestyle and quality in...
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The diverse functions of Pseudomonas syringae syringae van Hall effectors in regulating the plant immune response
Sorghum relies on its immune system to defend against various pathogens, including Pseudomonas syringae syringae van Hall ( Pss van Hall). However,...
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Peptide ILE-GLU-TRP (Stemokin) Potential Adjuvant Stimulating a Balanced Immune Response
Vaccines are widely used worldwide to prevent and protect from various infections. A variety of modern approaches to develo** prophylactic and...
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Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors...
