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Frameshift and wild-type proteins are often highly similar because the genetic code and genomes were optimized for frameshift tolerance
Frameshift mutations have been considered of significant importance for the molecular evolution of proteins and their coding genes, while frameshift...
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PRFect: a tool to predict programmed ribosomal frameshifts in prokaryotic and viral genomes
BackgroundOne of the stranger phenomena that can occur during gene translation is where, as a ribosome reads along the mRNA, various cellular and...
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Ribosomal proteins: the missing piece in the inflammation puzzle?
Ribosomal proteins (RPs) are constituents of macromolecular machinery, ribosome that translates genetic information into proteins. Besides ribosomal...
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ORFeus: a computational method to detect programmed ribosomal frameshifts and other non-canonical translation events
BackgroundIn canonical protein translation, ribosomes initiate translation at a specific start codon, maintain a single reading frame throughout...
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Rapid protein sequence evolution via compensatory frameshift is widespread in RNA virus genomes
BackgroundRNA viruses possess remarkable evolutionary versatility driven by the high mutability of their genomes. Frameshifting nucleotide insertions...
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Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome
Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA genome. The highly conserved frameshift stimulation element...
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Establishment and characterization of CSCRi006-A: an induced pluripotent stem cell line generated from a patient with Diamond-Blackfan Anemia (DBA) carrying ribosomal protein S19 (RPS19) mutation
Diamond-Blackfan anemia (DBA) is a congenital hypoplastic anemia characterized by ineffective erythropoiesis. DBA is majorly caused by mutations in...
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Combining Ribosomal Engineering with Heterologous Expression of a Regulatory Gene to Improve Milbemycin Production in Streptomyces milbemycinicus A2079
AbstractMilbemycin, a group of 16-membered macrolide antibiotics produced by Streptomyces milbemycinicus , has been widely used as an insecticide and...
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Complexities in viral replication strategies as a potential explanation for prevalence of asymptomatic carriers in Covid-19 infections: analytical observation on SARS-Cov2 genome characteristics
Analytical observations (in silico) indicate molecular features of SARS-Cov2 genome that potentially explains the high prevalence of asymptomatic...
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Comparative genome analysis of three euplotid protists provides insights into the evolution of nanochromosomes in unicellular eukaryotic organisms
One of the most diverse clades of ciliated protozoa, the class Spirotrichea, displays a series of unique characters in terms of eukaryotic...
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Recent Advancements in Ribosome Binding Site Prediction, Ribosome Profiling, and Structural Analysis in Prokaryotes
Ribosomal binding sites (RBSs) are short nucleotide sequences located upstream of the start codon of protein-coding genes that facilitate the binding...
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Long-read metagenomics retrieves complete single-contig bacterial genomes from canine feces
BackgroundLong-read sequencing in metagenomics facilitates the assembly of complete genomes out of complex microbial communities. These genomes...
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Translational Recoding and RNA Modifications
During protein synthesis, codons in mRNA are translated sequentially in frame on the ribosome following strict decoding rules. This process is...
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Mutation of the MYH3 gene causes recessive cleft palate in Limousine cattle
BackgroundThe palate is a structure separating the oral and nasal cavities and its integrity is essential for feeding and breathing. The total or...
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Starvation resistance in the nematode Pristionchus pacificus requires a conserved supplementary nuclear receptor
Nuclear hormone receptors (NHRs) are a deeply-conserved superfamily of metazoan transcription factors, which fine-tune the expression of their...
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Predicting tigecycline susceptibility in multidrug-resistant Klebsiella species and Escherichia coli strains of environmental origin
Tigecycline (TGC) is an important antimicrobial agent used as a last resort for difficult-to-treat infections mainly caused by carbapenem-resistant Enterobacteriaceae...
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Ribosome Hibernation: Molecular Strategy of Bacterial Survival (Review)
AbstractThis review concerns the mechanisms of bacterial cell survival based on the induction of hibernation factors (HFs) that suppress protein...
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Ribosome as a Translocase and Helicase
AbstractDuring protein synthesis, ribosome moves along mRNA to decode one codon after the other. Ribosome translocation is induced by a universally...
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Speciation Features of Ferdinandcohnia quinoae sp. nov to Adapt to the Plant Host
The bacterial strain SECRCQ15 T was isolated from seeds of Chenopodium quinoa in Spain. Phylogenetic, chemotaxonomic, and phenotypic analyses, as well...
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Expression of the human usherin c.2299delG mutation leads to early-onset auditory loss and stereocilia disorganization
Usher syndrome (USH) is the leading cause of combined deafness and blindness, with USH2A being the most prevalent form. The mechanisms responsible...
