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Genetic Testing in Recurrent Pregnancy Loss
Human pregnancy is a surprisingly inefficient process; approximately 5–10% of clinically recognized pregnancies end in miscarriages. Approximately...
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Are Altered Expression of Vascular Endothelial Growth Factor and Placental Growth Factor Associated with Placental Angiogenesis in Recurrent Pregnancy Loss?
Angiogenesis is one of the most important steps during pregnancy for placental and fetal development. Based on the hypothesis that vascular...
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A new enrichment approach for candidate gene detection in unexplained recurrent pregnancy loss and implantation failure
Recurrent pregnancy loss (RPL) and implantation failure (RIF) are obstacles to livebirth and multifactorial conditions in which nearly half of the...
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Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
BackgroundPregnancy is a complicated physiological process. The multifaceted regulation of maternal–fetal interface is of great importance for...
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The correlation of estrogen receptor 1 and progesterone receptor genes polymorphisms with recurrent pregnancy loss in a cohort of Egyptian women
Recurrent pregnancy loss (RPL) represents one of the pregnancy complications affecting 1–3% of women. Sex hormones, progesterone and estrogen play a...
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An imbalance of the IL-33/ST2-AXL-efferocytosis axis induces pregnancy loss through metabolic reprogramming of decidual macrophages
During embryo implantation, apoptosis is inevitable. These apoptotic cells (ACs) are removed by efferocytosis, in which macrophages are filled with a...
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Genome wide methylation analysis to uncover genes related to recurrent pregnancy loss
BackgroundRecurrent pregnancy loss (RPL) refers to two or more consecutive spontaneous abortion before 24 weeks of gestation, representing 1% of...
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Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss
Maintaining homeostasis of the decidual immune microenvironment at the maternal–fetal interface is essential for placentation and reproductive...
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Molecular investigation of association between common IL-6 polymorphism with cytomegalovirus (CMV) infection and recurrent miscarriage in Iranian women
BackgroundRecurrent pregnancy loss (RPL) is described as two or more spontaneous abortions. To date, scientists in various fields of knowledge, such...
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Evaluation of changes in exhausted T lymphocytes and miRNAs expression in the different trimesters of pregnancy in pregnant women
BackgroundThroughout the three trimesters of a typical pregnancy, we looked at changes in the expression of miRNAs and exhausted T lymphocytes for...
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Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice
ObjectiveRecurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular...
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YAP-mediated trophoblast dysfunction: the common pathway underlying pregnancy complications
Yes-associated protein (YAP) is a pivotal regulator in cellular proliferation, survival, differentiation, and migration, with significant roles in...
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Genetic Polymorphisms in MicroRNA-196a2 and the Risk of Human Abortion Related to Mycoplasma hominis
Mutations in some miRNAs are associated with human recurrent pregnancy loss (RPL). In parallel, Mycoplasma spp. are one of the most common infections...
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Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window
During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal...
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Genetic Counseling in Reproductive Medicine
Genetics is a rapidly changing landscape, and its applications have expanded into many areas of medicine, including human reproduction and...
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The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets
Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles originating from different cell compartments. EVs participate...
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The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases
Chromosomal translocations (CTs) are the most common type of structural chromosomal abnormalities in humans. CTs have been reported in several...
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JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2
Decidualization of human endometrial stromal cells (hESCs) is essential for the maintenance of pregnancy, which depends on the fine-tuned regulation...
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The association between cardiovascular disease gene mutations and recurrent pregnancy loss in the Lebanese population
Recurrent pregnancy loss (RPL) is a problem affecting up to 5% of women of childbearing age due to many factors. Studies have shown that RPL and...