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Assay of CB1 Receptor Binding
Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect...
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Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells
Displacement binding assays are nonfunctional assays mostly used with the aim of determining whether a certain compound (plant-derived or synthetic)...
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Untangling the Evolution of the Receptor-Binding Motif of SARS-CoV-2
The spike protein determines the host-range specificity of coronaviruses. In particular, the Receptor-Binding Motif in the spike protein from...
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LuBiA (Luciferase-Based Binding Assay): Glowing Peptides as Sensitive Probes to Study Ligand-Receptor Interactions
The quantitative and qualitative biochemical description of molecular interactions is fundamental to the study of ligand/receptor pairs and their...
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Repurposing of therapeutic antibodies against dengue virus envelope protein receptor binding domain
Dengue virus (DENV) is the leading cause of numerous deaths every year due to its high infectivity. In this study we have tried to target the DENV...
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Different receptor models show differences in ligand binding strength and location: a computational drug screening for the tick-borne encephalitis virus
The tick-borne encephalitis virus (TBE) is a neurotrophic disease that has spread more rapidly throughout Europe and Asia in the past few years. At...
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Properties and Activity of Peptide Derivatives of ACE2 Cellular Receptor and Their Interaction with SARS-CoV-2 S Protein Receptor-Binding Domain
AbstractThe aim of this work was to design and characterize peptides based on the α-helices h1 and h2 of the ACE2 receptor, forming the interaction...
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The NanoBiT-Based Homogenous Ligand–Receptor Binding Assay
NanoLuc Binary Technology (NanoBiT) was recently developed by Promega, based on a large NanoLuc fragment (LgBiT) and two small complementation tags,...
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A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
TGFβs, BMPs and Activins regulate numerous developmental and homeostatic processes and signal through hetero-tetrameric receptor complexes composed...
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Measuring Binding at the Putative Melatonin Receptor MT3
Melatonin, (N-acetyl-5-methoxytryptamine), is a neurohormone which possesses a wide range of biological effects. The effects mediated by melatonin...
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Assessing Estrogenic Activity of Classical Estrogen Receptor -Binding Compounds
The classical estrogen receptor α (ERα) has been a clinical therapeutic target for decades. ERα-targeted drugs have shown great clinical success, in...
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SARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody...
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Recombinant Insulin-Like Growth Factor 1 Dimers: Receptor Binding Affinities and Activation Abilities
Insulin-like growth factor 1 (IGF-1) and its IGF-1 receptor (IGF-1R) belong to an important biological system that is involved in the regulation of...
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Establishment of a steroid binding assay for goldfish membrane progesterone receptor (mPR) by coupling with graphene quantum dots (GQDs)
A homogeneous assay was developed to evaluate ligands that target the membrane progesterone receptor alpha (mPRα) of goldfish. This was achieved by...
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Genomic analysis uncovers that cold-inducible RNA binding protein is associated with estrogen receptor in breast cancer
BackgroundRNA-binding proteins (RBPs) perform various biological functions in humans and are associated with several diseases, including cancer....
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Comprehensive computational investigation for ligand recognition and binding dynamics of SdiA: a degenerate LuxR -type receptor in Klebsiella pneumoniae
SdiA is a LuxR-type receptor that controls the virulence of Klebsiella pneumoniae , a Gram-negative bacterium that causes various infections in...
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State-dependent binding of cholesterol and an anionic lipid to the muscle-type Torpedo nicotinic acetylcholine receptor
The ability of the Torpedo nicotinic acetylcholine receptor (nAChR) to undergo agonist-induced conformational transitions requires the presence of...
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Characterization of a novel tetravalent botulism antitoxin based on receptor-binding domain of BoNTs
AbstractBotulinum neurotoxin (BoNTs; serotypes A, B, E, and F) cause botulism disease in humans, which could be effectively treated using antitoxins....
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Systematic Profiling of Mitogen-Inducible Gene 6 and Its Derived Peptides Binding to Receptor Tyrosine Kinases in Bone Cancers at Molecular and Cellular Levels
Mitogen-inducible gene 6 (Mig6) is a tumor suppressor that inactivates oncogenic kinases by disrupting the dimerization of kinase domain using its...
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DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response
Effective and safe vaccines are invaluable tools in the arsenal to fight infectious diseases. The rapid spreading of severe acute respiratory...
