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RNA-Processing DNAzymes
The great potential of nucleic acids as therapeutics has been recognized for a while but has experienced a tremendous attention with the recent...
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DEAD Box RNA Helicases: Biochemical Properties, Role in RNA Processing and Ribosome Biogenesis
DEAD box RNA helicases are a versatile group of ATP dependent enzymes that play an essential role in cellular processes like transcription, RNA...
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An inexpensive semi-automated sample processing pipeline for cell-free RNA extraction
Despite advances in automated liquid handling and microfluidics, preparing samples for RNA sequencing at scale generally requires expensive...
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ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq
RNA processing, including splicing and alternative polyadenylation, is crucial to gene function and regulation, but methods to detect RNA processing...
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Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors
BackgroundThe human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage...
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The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing
BackgroundEpigenetic modifications of RNA significantly contribute to the regulatory processes in tumors and have, thus, received considerable...
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TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells
Differentiation of lens fiber cells involves a complex interplay of signals from growth factors together with tightly regulated gene expression via...
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Nanopore Direct RNA Sequencing Data Processing and Analysis Using MasterOfPores
This chapter describes MasterOfPores v.2 (MoP2), an open-source suite of pipelines for processing and analyzing direct RNA Oxford Nanopore sequencing...
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Elongation roadblocks mediated by dCas9 across human genes modulate transcription and nascent RNA processing
Non-cleaving Cas9 (dCas9) is widely employed to manipulate specific gene loci, often with scant regard for unintended transcriptional effects. We...
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Plant serine/arginine-rich proteins: versatile players in RNA processing
Main conclusionSerine/arginine-rich (SR) proteins participate in RNA processing by interacting with precursor mRNAs or other splicing factors to...
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Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding RNAs pivots around the regulated activity of RNA polymerase...
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Transkription: Biosynthese der RNA
Bei der Transkription wird die Nucleotidsequenz des DNA-Matrizenstrangs (-Strangs) eines Gens durch Basenpaarung in einen in 5′→ 3′-Richtung...
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Defining Bacterial RNA-RNA Interactomes Using CLASH
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen accounting for high mortality rates among infected patients....
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Mechanisms and functions of RNA-guided RNA modification
RNA-guided 2’-O-methylations and pseudouridylations occur in several different types of RNAs and in a wide range of organisms. Hundreds of the RNAs...
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Identification of RNA structures and their roles in RNA functions
The development of high-throughput RNA structure profiling methods in the past decade has greatly facilitated our ability to map and characterize...
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RNA-Seq Data Processing in Plant-Pathogen Interaction System: A Case Study
In RNA-seq data processing, short reads are usually aligned from one species against its own genome sequence; however, in plant-pathogen interaction...
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KARR-seq reveals cellular higher-order RNA structures and RNA–RNA interactions
RNA fate and function are affected by their structures and interactomes. However, how RNA and RNA-binding proteins (RBPs) assemble into higher-order...
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Short-Read RNA-Seq
RNA sequencing (RNA-Seq) has emerged as a powerful and versatile tool for the comprehensive analysis of transcriptomes and has been widely used to...
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Magic RNA
About half of the human genomeGenomes is actively transcribed as RNA, new regulatory and non-protein-coding RNA types such as miRNAs and lncRNAs in...