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1. Conversion of polyploid and alloploid Saccharomyces sensu stricto strains to leu2 mutants by genome DNA editing

   Abstract

   A large number of recombinant plasmids for the yeast Saccharomyces cerevisiae have been constructed and accumulated over the past four...

   Kazuya Kiyokawa, Tetsushi Sakuma, ... Katsunori Suzuki in Applied Microbiology and Biotechnology

   Article Open access 12 July 2024
   

2. The overlooked role of a biotin precursor for marine bacteria - desthiobiotin as an escape route for biotin auxotrophy

   Biotin (vitamin B ₇ ) is involved in a wide range of essential biochemical reactions and a crucial micronutrient that is vital for many pro- and...

   Gerrit Wienhausen, Stefan Bruns, ... Meinhard Simon in The ISME Journal

   Article Open access 13 August 2022
   

3. Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance

   Microbial communities are composed of cells of varying metabolic capacity, and regularly include auxotrophs that lack essential metabolic pathways....

   Jason S. L. Yu, Clara Correia-Melo, ... Markus Ralser in Nature Microbiology

   Article Open access 21 March 2022
   

4. Role of the mitochondrial citrate-oxoglutarate carrier in lipid accumulation in the oleaginous fungus Mortierella alpina

   Objectives

   The transport of citrate from the mitochondria to the cytoplasm is essential during lipid accumulation. This study aimed to explore the...

   Fengzhu Ling, **n Tang, ... Wei Chen in Biotechnology Letters

   Article 27 April 2021
   

5. Impact of direct physical association and motility on fitness of a synthetic interkingdom microbial community

   Mutualistic exchange of metabolites can play an important role in microbial communities. Under natural environmental conditions, such exchange may be...

   Giovanni Scarinci, Victor Sourjik in The ISME Journal

   Article Open access 24 December 2022
   

6. Random mutagenesis as a tool for industrial strain improvement for enhanced production of antibiotics: a review

   Secondary metabolites are produced by microbes in minimal quantities in the natural environment out of necessity. However, in the pharmaceutical...

   Sivakamavalli Jeyachandran, Prachi Vibhute, ... Chinnasamy Ragavendran in Molecular Biology Reports

   Article 15 December 2023
   

7. Short-Chain Fatty Acids Modulate Healthy Gut Microbiota Composition and Functional Potential

   Many studies have focused on the metabolic capacity of human gut microbiota to produce short-chain fatty acids and subsequent effects on host...

   Christine Tara Peterson, Josue Perez Santiago, ... Scott N. Peterson in Current Microbiology

   Article Open access 14 March 2022
   

8. High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availability

   Yeast cells survive in stationary phase culture by entering quiescence, which is measured by colony-forming capacity upon nutrient re-exposure. Yeast...

   Sean M. Santos, Samantha Laflin, ... John L. Hartman IV in GeroScience

   Article 05 October 2020
   

9. Methoden

   Bestimmte Arbeitsmethoden sind in der genetischen und molekularbiologischen Forschung zu Standards geworden. Obwohl ihr Ablauf im Detail von dem...

   Olaf G. Schmidt in Genetik und Molekularbiologie

   Chapter 2023
   

10. Larvae of a marine gastropod and a marine bivalve share common gene expression signatures during metamorphic competence

    Many aquatic invertebrates undergo an indirect development, a biphasic life cycle which encompasses the transformation of free-swimming larvae into...

    Zhen Zeng, Chongyi Jiang, ... Zixia Huang in Marine Biology

    Article Open access 01 September 2022
    

11. Is heterogeneity in large-scale bioreactors a real problem in recombinant protein synthesis by Pichia pastoris?

    Abstract

    Culture medium heterogeneity is inherent in industrial bioreactors. The loss of mixing efficiency in a large-scale bioreactor yields to the...

    Edgar Velastegui, Johan Quezada, ... Patrick Fickers in Applied Microbiology and Biotechnology

    Article 27 February 2023
    

12. Leucine supplementation mimics the effects of caloric restriction on yeast chronological lifespan

    Backgrounds

    Leucine prototrophic yeast exhibits extended longevity and related phenotypes similar to yeast grown under calorie restriction (CR)...

    Choco Michael Gorospe, Olumide Temitayo Jemiseye, Sung-Keun Lee in Molecular & Cellular Toxicology

    Article 01 October 2021
    

13. Yeasts of the Blastobotrys genus are promising platform for lipid-based fuels and oleochemicals production

    Abstract

    Strains of the yeast genus Blastobotrys (subphylum Saccharomycotina) represent a valuable biotechnological resource for basic biochemistry...

    Daniel Ruben Akiola Sanya, Djamila Onésime, ... Mahesh B. Khot in Applied Microbiology and Biotechnology

    Article 10 June 2021
    

14. Targeted Genetic Engineering via Agrobacterium-Mediated Transformation in Fusarium solani

    Members of the Fusarium solani species complex are filamentous fungi that can act as pathogens to many crops and animals. Although relevant, a robust...

    Mikkel Rank Nielsen, Samba Evelyne Kabemba Kaniki, Jens Laurids Sørensen in Engineering Natural Product Biosynthesis

    Protocol 2022
    

15. Expanding the toolbox: another auxotrophic marker for targeted gene integrations in Trichoderma reesei

    Background

    The filamentous ascomycete Trichoderma reesei is used for the industrial production of cellulases and holds the promise for heterologous...

    Paul Primerano, Melani Juric, ... Christian Derntl in Fungal Biology and Biotechnology

    Article Open access 14 September 2021
    

16. Experimental identification and in silico prediction of bacterivory in green algae

    While algal phago-mixotrophs play a major role in aquatic microbial food webs, their diversity remains poorly understood. Recent studies have...

    Nicholas A. Bock, Sophie Charvet, ... Eunsoo Kim in The ISME Journal

    Article Open access 02 March 2021
    

17. Vitamin B₁₂ is not shared by all marine prototrophic bacteria with their environment

    Vitamin B ₁₂ (cobalamin, herein B ₁₂ ) is an essential cofactor involved in amino acid synthesis and carbon resupply to the TCA cycle for most...

    Sabiha Sultana, Stefan Bruns, ... Gerrit Wienhausen in The ISME Journal

    Article Open access 13 March 2023
    

18. Fever-like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo

    Background

    Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) cause a wide variety of bacterial infections and coinfections, showing a...

    E. C. Solar Venero, M. B. Galeano, ... P. M. Tribelli in BMC Biology

    Article Open access 05 February 2024
    

19. Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC

    Genetically identical cells are known to differ in many physiological parameters such as growth rate and drug tolerance. Metabolic specialization is...

    Stephan Kamrad, Clara Correia-Melo, ... Markus Ralser in Nature Microbiology

    Article Open access 16 February 2023
    

20. Lincomycin-Induced Secondary Metabolism in Streptomyces lividans 66 with a Mutation in the Gene Encoding the RNA Polymerase Beta Subunit

    Activating the genetic potential of Streptomyces strains to produce secondary metabolites can improve the production of useful biologically active...

    Keiichiro Mukai, Momoko Kobayashi, ... Takeshi Hosaka in Current Microbiology

    Article 17 July 2020