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Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how proteins fold into their...
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Template-induced protein misfolding underlying prion diseases
Proteins with prion properties are closely associated to a class of fatal neurodegenerative illnesses in mammals and to the emergence and propagation...
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HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein-folding, quality...
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Calcium dysregulation potentiates wild-type myocilin misfolding: implications for glaucoma pathogenesis
AbstractMyocilin is secreted from trabecular meshwork cells to an eponymous extracellular matrix that is critical for maintaining intraocular...
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Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death
The prevalence of diabetes steadily increases worldwide mirroring the prevalence of obesity. Endoplasmic reticulum (ER) stress is activated in...
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Protein folding, misfolding, and un/non-folding: overview of the SP16 Session at the 20th IUPAB congress, 45th Annual Meeting of SBBf, and 50th Annual Meeting of SBBq
The classical and idealistic consideration of the protein universe as a set of well-ordered proteinaceous machines with unique spatial organizations...
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Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu,...
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Principles, Methods, and Applications of Protein Folding Inside Cells
The complex mechanism of protein folding in cells has intrigued the scientific community for decades. The physical and chemical forces that drive...
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Nuclear Magnetic Resonance Spectroscopy to Analyse Protein Folding and Dynamics
Proteins are nanoscale machines that perform all the work in living systems. Their function depends on their three-dimensional (3D) structure. These...
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Protein–Protein Interactions in Neurodegenerative Diseases
Neurodegeneration is a state of progressive decay of neuronal structure and function. It has gained scientific attention owing to the fact that...
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Distinct states of proinsulin misfolding in MIDY
A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements,...
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Protein Misfolding and Neurodegenerative Diseases
A protein must fold into a three-dimensional structure and maintain its tertiary/quaternary structure for proper function. To control all the vital...
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Unfolded Protein Response in Arabidopsis
The unfolded protein response (UPR) is a highly regulated signaling pathway that is largely conserved across eukaryotes. It is essential for cell...
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Hsp104p: a protein disaggregase
All newly synthesized proteins must fold to their correct native conformation in order to function. That protein folding in the crowded...
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LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits
Protein misfolding is a major factor of neurodegenerative diseases. Post-mitotic neurons are highly susceptible to protein aggregates that are not...
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SNPeffect 5.0: large-scale structural phenoty** of protein coding variants extracted from next-generation sequencing data using AlphaFold models
BackgroundNext-generation sequencing technologies yield large numbers of genetic alterations, of which a subset are missense variants that alter an...
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Recombinant Protein Production and Purification of Insoluble Proteins
Proteins are synthesized in heterologous systems because of the impossibility to obtain satisfactory yields from natural sources. The efficient...
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The Promising Role of Selenium and Yeast in the Fight Against Protein Amyloidosis
In recent years, increasing attention has been paid to research on diseases related to the deposition of misfolded proteins (amyloids) in various...
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The protein disorder cycle
This mini-review represents a brief, disorder-centric consideration of the interplay between order and disorder in proteins. The goal here is to show...
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Quantification of Protein Exit at the Trans-Golgi Network
With one-third of all newly synthesized proteins entering the secretory pathway, correct protein sorting is essential for cellular homeostasis. In...