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Differentiated pre-adipocytes promote proliferation, migration and epithelial-mesenchymal transition in breast cancer cells of different p53 status
Breast cancer progression and metastasis are associated with stromal cells in the tumor microenvironment. Adipocytes are the most abundant cells...
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miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes
MicroRNAs (miRNAs) are potent regulators of multiple biological processes. Previous studies have demonstrated that miR-146a-5p increases in normal...
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Quercetin declines LPS induced inflammation and augments adiponectin expression in 3T3-L1 differentiated adipocytes SIRT-1 dependently
BackgroundInflammation is an important factor contributing to obesity-induced metabolic disorders. Different investigations confirm that local...
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The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites
White to brown/beige adipocytes conversion is a possible therapeutic strategy to tackle the current obesity epidemics. While mitochondria are key for...
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Intrapancreatic fat, pancreatitis, and pancreatic cancer
Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms of treatment, contributing to poor survival outcomes....
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Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation
Histone methylation plays a crucial role in various cellular processes. We previously reported the in vitro function of histone lysine demethylase...
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Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices
BackgroundThe vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications....
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Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy
Tumorigenic Cancer Stem Cells (CSCs), often called tumor-initiating cells (TICs), represent a unique subset of cells within the tumor milieu. They...
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Reprogramming Human Female Adipose Mesenchymal Stem Cells into Primordial Germ Cell-Like Cells
In the last two decades, considerable progress has been made in the derivation of mammalian germ cells from pluripotent stem cells such as Embryonic...
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Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3
Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-associated metabolic diseases. Interferon regulatory factor 3...
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Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage
BackgroundInteractions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The...
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Alterations in niban gene expression as a response to stress conditions in 3T3-L1 adipocytes
Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment....
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Macrophage plays important role in cortisol and serotonin induced adipogenesis in vitro
Psychological stress is an important cause to induce various metabolic disorders such as obesity, type II diabetes, and cardiovascular disorders by...
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Differentiation of Fibroblasts to Adipocytes in 3D for a Co-culture with Mammary Organoids and Immunohistological Analysis
Mammary epithelial ducts, the main functional compartment of the mammary gland, are embedded in an adipocyte-rich stroma, which is essential for...
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Pre-enrichment of Adipose Tissue Grafts: Potential and Limitations
Autologous adipose tissue grafts are commonly used by plastic and aesthetic surgeons in various medical procedures for soft-tissue augmentation and...
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A Simple Method for Generating, Clearing, and Imaging Pre-vascularized 3D Adipospheres Derived from Human iPS Cells
Beige/brite/brown-like adipocytes (BAs), dispersed in white adipose tissue, represent promising cell targets to counteract obesity and associated...
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A novel conjunctive microenvironment derived from human subcutaneous adipose tissue contributes to physiology of its superficial layer
BackgroundIn human subcutaneous adipose tissue, the superficial fascia distinguishes superficial and deep microenvironments showing extensions called...
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Repurposing Decellularized Lung to Generate Vascularized Fat
Conventional therapies to address critically sized defects in subcutaneous adipose tissue remain a reconstructive challenge for surgeons, largely due...
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Isolation of Human Adipose-Derived Stromal/Stem Cells from Lipoaspirates
Adipose tissue is an abundant and accessible source of stem cells with multipotent properties suitable for tissue engineering and regenerative...
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Soft Tissue Reconstruction
Autologous fat transplantation has revolutionized soft tissue reconstruction, but conventional methods remain unpredictable as graft resorption rates...