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Effects of Polyphosphate on Leukocyte Function
Leukocytes are immune cells derived from hematopoietic stem cells of the bone marrow which play essential roles in inflammatory and immune responses....
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Lipid-Derived Mediators are Pivotal to Leukocyte and Lung Cell Responses in Sepsis and ARDS
Acute inflammation in the lung is essential for host defense against pathogens and other injuries but chronic or excessive inflammation can...
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Microorganisms isolated from the bile of the patients who have undergone cholecystectomy and their antibiotic resistance pattern: multicenter prospective study
BackgroundGallbladder and biliary tract infections are diseases with high mortality rates if they are not treated properly. Microbiological...
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Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes
BackgroundDairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro...
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Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica
Mannheimia haemolytica is the main bacterial pathogen isolated in bovine respiratory disease (BRD), a common disease affecting calves before weaning....
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β2-integrins in Immunity: New Roles for Old Players
β2-integrins are adhesion- and mechanoreceptors expressed exclusively on leukocytes. They mediate diverse functions in immunity and are of...
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Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model
Photoreceptor cell death and immune cell infiltration are two major events that contribute to retinal degeneration. However, the relationship between...
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Calcium-sensing receptor and NF-κB pathways in TN breast cancer contribute to cancer-induced cardiomyocyte damage via activating neutrophil extracellular traps formation
Cardiovascular disorders are commonly prevalent in cancer patients, yet the mechanistic link between them remains poorly understood. Because...
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Neutralization of the Staphylococcus aureus Panton-Valentine leukocidin by African and Caucasian sera
BackgroundThe prevalence of Staphylococcus aureus isolates carrying the Panton-Valentine leukocidin (PVL) gene is higher in Africa (≈50%) compared...
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Diabetes and Infectious Diseases with a Focus on Melioidosis
Diabetes mellitus (DM) leads to impaired innate and adaptive immune responses. This renders individuals with DM highly susceptible to microbial...
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Emerging In Vitro Models for the Study of Infection and Pathogenesis of Pseudomonas aeruginosa and Testing of Antibacterial Agents
Several animal models have been developed to study infection strategies and pathogenesis of Pseudomonas aeruginosa. Some of these models are also...
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The effect of local anaesthetics on apoptosis and NETosis of human neutrophils in vitro: comparison between lidocaine and ropivacaine
There are immunological consequences to the method by which neutrophils undergo cell death. Neutrophil apoptosis, called silent death, leads to the...
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Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis
Bovine mastitis, an inflammatory disease of the mammary gland, is classified as subclinical or clinical. Circulating neutrophils are recruited to the...
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Inflammation and neutrophil extracellular traps in cerebral cavernous malformation
Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various neurological symptoms. In this study, we describe the inflammatory...
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Integrins α1β1 and α2β1: The Generalist Collagen Receptors
Four members of the large integrin family have the capability to directly recognize specific collagenous motifs in proteins. These integrins can be...
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IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms
IntroductionThe clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However...
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Bioactive Bone Substitute in a Rabbit Ulna Model: Preclinical Study
Background:Current therapies to effectively treat long-bone defects and extensive bone tissue loss remains limited. In this study, we created a new...
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Bioinformatics analysis of paravertebral muscles atrophy in adult degenerative scoliosis
Paravertebral muscles (PVM) act as one of the major dynamic factors to maintain human upright activities and play a remarkable role in maintaining...
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Leukocytospermia induces intraepithelial recruitment of dendritic cells and increases SIV replication in colorectal tissue explants
Mucosal exposure to infected semen accounts for the majority of HIV-1 transmission events, with rectal intercourse being the route with the highest...
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Dynamic immune response characteristics of piglets infected with Actinobacillus pleuropneumoniae through omic
Porcine infectious pleuropneumonia is characterized by a high-rate of carriage and mixed infection with other pathogens. The host immune response...
