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Platelet-Derived Growth Factor-BB Priming Enhances Vasculogenic Capacity of Bone Marrow-Derived Endothelial Precursor Like Cells
Background:Human endothelial progenitor cells (EPCs) were first identified in the peripheral blood and later in the cord blood and bone marrow (BM)...
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Optimization of a Purification Method for the Recombinant Platelet-Derived Growth Factor rhPDGF-BB Expressed in the Methylotrophic Yeast Pichia Pastoris
Recombinant human platelet-derived growth factor rhPDGF-BB is one of the major cytokines that has been approved for medical use. Medical drug...
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Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway
BackgroundVascular abnormalities in the ovary cause infertility accompanied by ovarian insufficiency due to a microenvironment of barren ovarian...
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Activation of cell adhesion and migration is an early event of platelet-rich plasma (PRP)-dependent stimulation of human adipose-derived stem/stromal cells
Stem cell therapy is a promising treatment in regenerative medicine. Human adipose-derived stem/stromal cells (hASCs), a type of mesenchymal stem...
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Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions
Ischemic stroke induces neovascularization of the injured tissue as an attempt to promote structural repair and neurological recovery. Angiogenesis...
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The effect of genetically modified platelet-derived growth factor-BB over-expressing mesenchymal stromal cells during core decompression for steroid-associated osteonecrosis of the femoral head in rabbits
BackgroundApproximately one third of patients undergoing core decompression (CD) for early-stage osteonecrosis of the femoral head (ONFH) experience...
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Differentiation of human adipose-derived mesenchymal stem cells toward tenocyte by platelet-derived growth factor-BB and growth differentiation factor-6
Mesenchymal Stem Cells (MSCs) are important in regenerative medicine and tissue engineering and will be a very sensible choice for repair and...
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Exploring platelet-derived microvesicles in vascular regeneration: unraveling the intricate mechanisms and molecular mediators
Microvesicles (MVs) serve as biomarkers and transmitters for cell communication and also act as essential contributors to diseases. Platelets release...
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Induction of tenogenic differentiation of equine adipose-derived mesenchymal stem cells by platelet-derived growth factor-BB and growth differentiation factor-6
Managing tendon healing process is complicated mainly due to the limited regeneration capacity of tendon tissue. Mesenchymal stem cells (MSCs) have...
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SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
BackgroundThe platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors...
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Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse
Patients with estrogen receptor (ER)-positive breast cancer are at risk of metastatic relapse for decades after primary tumor resection and...
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Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and...
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PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
The nitric oxide-cGMP (NO-cGMP) pathway is of outstanding importance for vascular homeostasis and has multiple beneficial effects in vascular...
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In-situ gelation of fibrin gel encapsulating platelet-rich plasma-derived exosomes promotes rotator cuff healing
Although platelet-rich plasma-derived exosomes (PRP-Exos) hold significant repair potential, their efficacy in treating rotator cuff tear (RCT)...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
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Human platelet lysate-cultured adipose-derived stem cell sheets promote angiogenesis and accelerate wound healing via CCL5 modulation
BackgroundA rising population faces challenges with healing-impaired cutaneous wounds, often leading to physical disabilities. Adipose-derived stem...
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The effect of the anticoagulant on the cellular composition and growth factor content of platelet-rich plasma
BackgroundThe cellular and biochemical composition of the platelet rich plasma (PRP) may impact its regenerative capacity. PRP composition have been...
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Human platelet lysate stimulates neurotrophic properties of human adipose-derived stem cells better than Schwann cell-like cells
BackgroundTrauma-associated peripheral nerve injury is a widespread clinical problem causing sensory and motor disabilities. Schwann cells (SCs)...
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Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis
In the cornea, the epithelial basement membrane (EBM) and corneal endothelial Descemet’s basement membrane (DBM) critically regulate the...
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Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling
Interaction of platelet-derived growth factor (PDGF) isoforms with their receptors results in activation and internalization of receptors, with a...
