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Combined transcriptomic and metabolomic analysis of Salmonella in the presence or absence of PhoP–PhoQ system under low Mg2+ conditions
IntroductionPrevious reports revealed the role played by Salmonella PhoP–PhoQ system in virulence activation, antimicrobial tolerance and...
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Nitric oxide is a host cue for Salmonella Typhimurium systemic infection in mice
Nitric oxide (NO) is produced as an innate immune response against microbial infections. Salmonella Typhimurium ( S . Typhimurium), the major causative...
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Influence of PhoPQ and PmrAB two component system alternations on colistin resistance from non-mcr colistin resistant clinical E. Coli strains
BackgroundThe current understanding of acquired chromosomal colistin resistance mechanisms in Enterobacterales primarily involves the disruption of...
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Acid tolerance response of Salmonella during the squid storage and its amine production capacity analysis
Salmonella exhibits a strong inducible acid tolerance response (ATR) under weak acid conditions, and can also induce high-risk strains that are...
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Genomic variations in polymyxin-resistant Pseudomonas aeruginosa clinical isolates and their effects on polymyxin resistance
Infection with P. aeruginosa , one of the most relevant opportunistic pathogens in hospital-acquired infections, can lead to high mortality due to its...
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Oral Delivery of SARS-CoV-2 DNA Vaccines Using Attenuated Salmonella typhimurium as a Carrier in Rat
AbstractThe 2019 novel coronavirus disease (COVID-19) is the disease that has been identified as severe acute respiratory syndrome coronavirus 2...
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Prevalence and molecular characterization of colistin resistance in Pseudomonas aeruginosa isolates: insights from a study in Ardabil hospitals
BackgroundPseudomonas aeruginosa is a common cause of nosocomial infections. However, the emergence of multidrug-resistant strains has complicated...
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The PhoPR two-component system responds to oxygen deficiency and regulates the pathways for energy supply in Corynebacterium glutamicum
The PhoPR two-component system, a highly conserved system in corynebacteria and mycobacteria, is involved in the cellular response to environmental...
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Histidine Kinase PhoQ Is a Critical Regulator for Selenium Metabolism in Rahnella aquatilis HX2 and Enhances Selenium Bioavailability in Soil
PhoP/PhoQ, the two-component regulatory system, plays a significant role in regulating the functions of many Gram-negative bacteria. This study...
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Molecular characterization of colistin resistance genes in a high-risk ST101/KPC-2 clone of Klebsiella pneumoniae in a University Hospital of Split, Croatia
Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) has become a major concern worldwide due to multidrug resistance and the ability...
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Occurrence of virulence factors and carbapenemase genes in Salmonella enterica serovar Enteritidis isolated from chicken meat and egg samples in Iraq
BackgroundFood-borne infections mainly due to Salmonella enterica serovar Enteritidis ( S . Enteritidis) are major concerns worldwide. S . Enteritidis...
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PhoPQ two-component regulatory system plays a global regulatory role in antibiotic susceptibility, physiology, stress adaptation, and virulence in Stenotrophomonas maltophilia
BackgroundStenotrophomonas maltophilia , an opportunistic pathogen, is ubiquitously present in various environments, signifying its high capability...
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Genoty** of paired KPC-producing Klebsiella pneumoniae isolates with and without divergent polymyxin B susceptibility profiles
Polymyxins are still used mainly in treating infections caused by carbapenem-resistant Klebsiella pneumoniae worldwide. The most frequent mechanism...
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The Hha–TomB toxin–antitoxin module in Salmonella enterica serovar Typhimurium limits its intracellular survival profile and regulates host immune response
The key to bacterial virulence relies on an exquisite balance of signals between microbe and hosts. Bacterial toxin–antitoxin (TA) system is known to...
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Regulation of gene expression by protein lysine acetylation in Salmonella
Protein lysine acetylation influences many physiological functions, such as gene regulation, metabolism, and disease in eukaryotes. Although little...
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Detection of colistin-resistant populations prior to antibiotic exposure in KPC-2-producing Klebsiella pneumoniae clinical isolates
Although colistin is frequently regarded as the antibiotic of last resort in treating carbapenem-resistant Klebsiella pneumoniae , colistin...
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An overview on the two-component systems of Streptomyces coelicolor
The two-component system (TCS) found in various organisms is a regulatory system, which is involved in the response by the organism to stimuli,...
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A review on surfactin: molecular regulation of biosynthesis
Surfactin has many biological activities, such as inhibiting plant diseases, resisting bacteria, fungi, viruses, tumors, mycoplasma, anti-adhesion,...
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Trends in the two-component system’s role in the synthesis of antibiotics by Streptomyces
AbstractDespite the advances in understanding the regulatory networks for secondary metabolite production in Streptomyces , the participation of the...
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Antimicrobial peptide glatiramer acetate targets Pseudomonas aeruginosa lipopolysaccharides to breach membranes without altering lipopolysaccharide modification
Antimicrobial peptides (AMPs) are key components of innate immunity across all domains of life. Natural and synthetic AMPs are receiving renewed...
