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Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration
BACKGROUND:Repair of long-distance peripheral nerve defects remains an important clinical problem. Nerve grafts incorporated with extracellular...
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Potential Application of Orofacial MSCs in Tissue Engineering Nerve Guidance for Peripheral Nerve Injury Repair
Injury to the peripheral nerve causes potential loss of sensory and motor functions, and peripheral nerve repair (PNR) remains a challenging...
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Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is...
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Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models
BACKGROUND:Peripheral nerve damage mainly resulted from traumatic or infectious causes; the main signs of a damaged nerve are the loss of sensory...
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Cell-free therapy based on extracellular vesicles: a promising therapeutic strategy for peripheral nerve injury
Peripheral nerve injury (PNI) is one of the public health concerns that can result in a loss of sensory or motor function in the areas in which...
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Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration
BackgroundNerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in...
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Transplanted neural lineage cells derived from dental pulp stem cells promote peripheral nerve regeneration
Cell therapy for peripheral nerve injury is a promising strategy as regenerative medicine that restores neurological function. However, challenges...
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Augmenting Peripheral Nerve Regeneration with Adipose-Derived Stem Cells
Peripheral nerve injuries (PNIs) are common and debilitating, cause significant health care costs for society, and rely predominately on autografts,...
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Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons
BackgroundSevere peripheral nerve injury (PNI) often leads to significant movement disorders and intractable pain. Therefore, promoting nerve...
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Biomimetic nerve guidance conduit containing engineered exosomes of adipose-derived stem cells promotes peripheral nerve regeneration
BackgroundEfficient and stable delivery of neurotrophic factors (NTFs) is crucial to provide suitable microenvironment for peripheral nerve...
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Functional tissue-engineered microtissue formed by self-aggregation of cells for peripheral nerve regeneration
BackgroundPeripheral nerve injury (PNI) is one of the essential causes of physical disability with a high incidence rate. The traditional tissue...
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Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration
Wallerian degeneration (WD) involves the recruitment of macrophages for debris clearance and nerve regeneration, and the cause of the foamy...
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Leukemia inhibitory factor regulates Schwann cell proliferation and migration and affects peripheral nerve regeneration
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that stimulates neuronal development and survival. Our previous study has demonstrated...
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Peripheral Nerve Regeneration Using a Nerve Conduit with Olfactory Ensheathing Cells in a Rat Model
BACKGROUND:Autologous nerve grafts are the gold standard treatment for peripheral nerve injury treatment. However, this procedure cannot avoid...
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IL4 stimulated macrophages promote axon regeneration after peripheral nerve injury by secreting uPA to stimulate uPAR upregulated in injured axons
Accumulating evidences suggest that M2 macrophages are involved with repair processes in the nervous system. However, whether M2 macrophages can...
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Inverted human umbilical artery as a 3D scaffold for sciatic nerve regeneration in rats
Treatment of peripheral nerve injuries (PNIs) remains a challenge. Interposing a graft delivers better regenerative outcomes. Autografts present...
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Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts
Background:Schwann cells (SCs) secrete neurotrophic factors and provide structural support and guidance during axonal regeneration. However, nearby...
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Human Adipose-Derived Stem Cells Delay Muscular Atrophy after Peripheral Nerve Injury in Rats
IntroductionGiven that denervation atrophy often occurs in muscle after peripheral nerve injury, the effects of injections of human adipose-derived...
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HIF-1α-induced upregulation of m6A reader IGF2BP1 facilitates peripheral nerve injury recovery by enhancing SLC7A11 mRNA stabilization
The recovery of peripheral nerve injury (PNI) is not ideal in clinic. Our previous study revealed that hypoxia treatment promoted PNI repair by...
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Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury
Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory...
