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A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia
Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in...
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Chronic myeloid leukemia stem cells: targeting therapeutic implications
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-ABL1 oncoprotein, which plays a pivotal role in CML pathology,...
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An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and limited treatment options. Here we provide a comprehensive census...
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Mitochondrial oxidative phosphorylation is dispensable for survival of CD34+ chronic myeloid leukemia stem and progenitor cells
Chronic myeloid leukemia (CML) are initiated and sustained by self-renewing malignant CD34 + stem cells. Extensive efforts have been made to reveal...
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Graft failure after allogeneic hematopoietic stem cell transplantation in pediatric patients with acute leukemia: autologous reconstitution or second transplant?
BackgroundGraft failure (GF) is a rare but serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Prevention of graft...
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The potential role of renin angiotensin system in acute leukemia: a narrative review
Acute leukemias (ALs) are the most common cancers in pediatric population. There are two types of ALs: acute lymphoblastic leukemia (ALL) and acute...
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The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting
Acute myeloid leukemia (AML) is a hematological malignancy characterized by cytogenetic and genomic alterations. Up to now, combination chemotherapy...
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TPEN selectively eliminates lymphoblastic B cells from bone marrow pediatric acute lymphoblastic leukemia patients
B-cell acute lymphoblastic leukemia (B-ALL) is a hematologic disorder characterized by the abnormal proliferation and accumulation of immature...
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Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML
BackgroundCancer patients can achieve dramatic responses to chemotherapy yet retain resistant tumor cells, which ultimately results in relapse....
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Whole exome sequencing of pediatric leukemia reveals a novel InDel within FLT-3 gene in AML patient from Mizo tribal population, Northeast India
BackgroundLeukemia is the most common type of cancer in pediatrics. Genomic mutations contribute towards the molecular mechanism of disease...
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An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications
Arsenic trioxide is a first-line treatment drug for acute promyelocytic leukemia, which is also effective for other kinds of leukemia. Its side...
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The prognostic role of C-KIT, TET1 and TET2 gene expression in Acute Myeloid Leukemia
Aimwas to assess the role of C-KIT , TET1 and TET2 expression in the diagnosis and prognosis of acute myeloblastic leukemia (AML).
Methods ...
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The Role of PHF6 in Hematopoiesis and Hematologic Malignancies
Epigenetic regulation of gene expression represents an important mechanism in the maintenance of stem cell function. Alterations in epigenetic...
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Chronic Granulomatous Disease
Chronic granulomatous disease (CGD) is an immunodeficiency that affects phagocytic leukocytes (neutrophils, monocytes, macrophages and eosinophils)....
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The IKAROS Transcription Factor Gene IKZF1 as a Critical Regulator in the Pathogenesis of Childhood Acute Lymphoblastic Leukemia: Insights from a Bangladeshi Population
The IKZF1 transcription factor gene plays a pivotal role in the commitment of multipotent progenitors to common lymphoid progenitors during...
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Acute lymphoblastic leukemia displays a distinct highly methylated genome
DNA methylation is tightly regulated during development and is stably maintained in healthy cells. In contrast, cancer cells are commonly...
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Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers
Analysis of mutational signatures can reveal underlying molecular mechanisms of the processes that have imprinted the somatic mutations found in...
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Advancements in small interfering RNAs therapy for acute lymphoblastic leukemia: promising results and future perspectives
Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children, presenting significant healthcare challenges for some patients,...
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Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia
Due to its potent cytotoxicity in BRCA-mutated tumors, synthetic lethality elicited by poly (ADP-ribose) polymerase (PARP) inhibitor gives renewed...
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Interplay between proteasome inhibitors and NF-κB pathway in leukemia and lymphoma: a comprehensive review on challenges ahead of proteasome inhibitors
The current scientific literature has extensively explored the potential role of proteasome inhibitors (PIs) in the NF-κB pathway of leukemia and...
