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Pancreatic Differentiation of Oral Minor Salivary Gland Stem Cells
IntroductionStem cells from various sources including major salivary glands have been used to establish pancreatic differentiation in an attempt to...
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p53 Inhibition in Pancreatic Progenitors Enhances the Differentiation of Human Pluripotent Stem Cells into Pancreatic β-Cells
The multipotent pancreatic progenitor cells (MPCs) co-expressing the transcription factors, PDX1 and NKX6.1, are the source of functional pancreatic...
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The Promises of Pancreatic Progenitor Proliferation and Differentiation
Human pluripotent stem cells (hPSCs) have been proposed as an unlimited source of insulin-secreting pancreatic β cells for diabetes treatment. Many...
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Chemical inhibitors of cyclin-dependent kinase (CDKi) improve pancreatic endocrine differentiation of iPS cells
Islet transplantation, including pancreatic beta cells, has become an approved treatment for type I diabetes. To date, the number of donors limits...
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Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with small molecules
The efficiency of inducing human embryonic stem cells into NEUROG3+ pancreatic endocrine cells is a bottleneck in stem cell therapy for diabetes. To...
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Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions
Despite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor...
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Photo-click hydrogels for 3D in situ differentiation of pancreatic progenitors from induced pluripotent stem cells
BackgroundInduced pluripotent stem cells (iPSC) can be differentiated to cells in all three germ layers, as well as cells in the extraembryonic...
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Restoring β Cells Population Through In Situ Differentiation of Residential Pancreatic Cells
Diabetes mellitus (DM) is a global health problem leading to morbidity, mortality, and compromising the quality of life. DM is well characterized by...
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Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation
Heparanase 2 (Hpa2, HPSE2 ) is a close homolog of heparanase. Hpa2, however, lacks intrinsic heparan sulfate (HS)-degrading activity, the hallmark of...
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Optimization of differentiation protocols of dental tissues stem cells to pancreatic β-cells
BackgroundDespite the recent progress in the differentiation strategies of stem cells into pancreatic beta cell lineage, current protocols are not...
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Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be...
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Single-cell analyses reveal distinct expression patterns and roles of long non-coding RNAs during hESC differentiation into pancreatic progenitors
BackgroundDeep understanding the differentiation process of human embryonic stem cells (hESCs) is essential for develo** cell-based therapeutic...
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Restoring β Cells Population Through In Situ Differentiation of Residential Pancreatic Cells
Diabetes mellitus (DM) is a global health problem leading to morbidity, mortality, and compromising the quality of life. DM is well characterized by...
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Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
Cell type specification during pancreatic development is tightly controlled by a transcriptional and epigenetic network. The precise role of most...
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Improved Differentiation of hESC-Derived Pancreatic Progenitors by Using Human Fetal Pancreatic Mesenchymal Cells in a Micro‐scalable Three-Dimensional Co-culture System
Mesenchymal cells of diverse origins differ in gene and protein expression besides producing varying effects on their organ-matched epithelial cells’...
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Development of a 48-Well Dynamic Suspension Culture System for Pancreatic Differentiation from Human Embryonic Stem Cells
BackgroundHuman pluripotent stem cells (hPSCs) have started to emerge as a potential tool with application in fields of drug discovery, disease...
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iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
Recently, we reported that forkhead box A2 (FOXA2) is required for the development of human pancreatic α- and β-cells. However, whether miRNAs play a...
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Epigenetic Alterations in Pancreatic Cancer
The occurrence of pancreatic cancer (PC) is presented to have risen in the past few years. Pancreatic cancer includes 5% of all cancer-related deaths...
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Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis
Some individuals develop prediabetes and/or diabetes following acute pancreatitis (AP). AP-induced beta-cell injury and the limited regenerative...
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Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis
AbstractOptimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the generation of diverse organ-like structures. In...
