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Diminished NAD+ levels and activation of retrotransposons promote postovulatory aged oocyte (POAO) death
Death is the fate of postovulatory aged or unfertilized oocytes (POAO) in many animals. However, precise molecular mechanisms are yet to be...
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Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth
BackgroundMammalian follicle development is characterized by extensive changes in morphology, endocrine responsiveness, and function, providing the...
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The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging
Despite the advances in the understanding of reproductive physiology, the mechanisms underlying ovarian aging are still not deciphered. Recent...
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Oocyte Casein kinase 1α deletion causes defects in primordial follicle formation and oocyte loss by impairing oocyte meiosis and enhancing autophagy in develo** mouse ovary
Casein kinase 1α is a member of CK1 family, which is ubiquitously expressed and plays multiple functions, including its potential roles in regulating...
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LSM14B controls oocyte mRNA storage and stability to ensure female fertility
Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic development. However, how to regulate mRNA storage and...
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Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging
BackgroundOocyte quality is critical for the mammalian reproduction due to its necessity on fertilization and early development. During aging, the...
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Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis
Kinesin family member 3A (KIF3A) is a microtubule-oriented motor protein that belongs to the kinesin-2 family for regulating intracellular transport...
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Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy
With aging, abnormalities during oocyte meiosis become more prevalent. However, the mechanisms of aging-related oocyte aneuploidy are not fully...
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SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation
Germ cell division and differentiation require intimate contact and interaction with the surrounding somatic cells. Luteinizing hormone (LH) triggers...
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Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging
Advanced age is a primary risk factor for female infertility due to reduced ovarian reserve and declining oocyte quality. However, as an important...
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Influence of the Ovarian Reserve and Oocyte Quality on Livestock Fertility
Functional traits of livestock species such as health and reproduction have a substantial effect on profitability. Poor reproduction limits livestock...
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Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
BackgroundImmature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive...
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Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment
The fertilizing spermatozoon is a highly specialized cell that selects from millions along the female tract until the oocyte. The paternal components...
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Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
BackgroundThe oocyte-to-embryo transition (OET) converts terminally differentiated gametes into a totipotent embryo and is critically controlled by...
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Kinesin KIFC3 is essential for microtubule stability and cytokinesis in oocyte meiosis
KIFC3 is a member of Kinesin-14 family motor proteins, which play a variety of roles such as centrosome cohesion, cytokinesis, vesicles...
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NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
BackgroundMembers of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various...
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In vitro post-ovulatory oocyte ageing in grass carp Ctenopharyngodon idella affects H4K12 acetylation pattern and histone acetyltransferase activity
Delayed fertilization leads to the ageing of post-ovulatory oocytes and reduces the developmental competence of arising embryos. Little information...
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Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation
DNA cytosine methylation plays a vital role in repressing retrotransposons, and such derepression is linked with developmental failure, tumorigenesis...
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Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of K+ in promoting yolk globule fusion and regulating oocyte maturation
Schizothorax oconnori ( S. oconnori ) is an economically important fish in Tibet. Oocyte maturation is a physiological process that is of great...
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Oocyte quality assessment in marine invertebrates: a novel approach by fluorescence spectroscopy
BackgroundThe assessment of oocyte quality is, nowadays, a major challenge in aquaculture, oocyte cryopreservation, and environmental science. Oocyte...
