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The CEPH aging cohort and biobank: a valuable collection of biological samples from exceptionally long-lived French individuals and their offspring for longevity studies
The increasing aging of the human population is currently and for the coming decades a major public health issue in many countries, requiring the...
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Differential impacts of adult trees on offspring and non-offspring recruits in a subtropical forest
An important mechanism promoting species coexistence is conspecific negative density dependence (CNDD), which inhibits conspecific neighbors by...
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Prospective Intergenerational Consequences of Paternal Stress Experiences on Offspring Immune Health
A close relationship between immune regulation and neuropsychiatric disorders is becoming more apparent. Studies have now uncovered key mechanisms...
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Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
Maternal age at childbearing has continued to increase in recent decades. However, whether and how it influences offspring adult traits are largely...
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Effect of a High-Fat Diet and Probiotic Supplementation on the Gut Microbiota of Maternal Mice at Term Pregnancy and Offspring at Three-Week Postpartum
The effects of probiotics on the gut microbiota in maternal mice-fed high-fat diet (HFD) during pregnancy and offspring are still unknown. We aimed...
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Familial aggregation of the aging process: biological age measured in young adult offspring as a predictor of parental mortality
Measures of biological age (BA) integrate information across organ systems to quantify “biological aging,” i.e., inter-individual differences in...
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Multiplicity of sperm receptacles for securing the offspring genetic variability in a pelagic squid
Female eumetazoans often develop sperm storage organs (SSOs). Although the processes of sperm storage may influence sperm competition and cryptic...
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The influence of maternal unhealthy diet on maturation of offspring gut microbiota in rat
BackgroundDespite well-known effects of diet on gut microbiota diversity, relatively little is known about how maternal diet quality shapes the...
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Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
BackgroundCannabis legalization is expanding and men are the predominant users. We have limited knowledge about how cannabis impacts sperm and...
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Unhealthy Lifestyle Behaviors During Pregnancy and Offspring Health Risks at Birth and Early Childhood
Pregnancy is a special stage linked to various biopsychosocial changes. Lifestyle behaviors during pregnancy may change along social, mental and...
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Amphibian breeding phenology influences offspring size and response to a common wetland contaminant
BackgroundIncreases in temperature variability associated with climate change have critical implications for the phenology of wildlife across the...
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iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion
BackgroundThe genetic factors associated with insulin resistance (IR) are not well understood. Clinical studies on first-degree relatives of type 2...
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Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring
Various environmental exposures during pregnancy, like maternal diet, can compromise, at critical periods of development, the neurovascular...
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Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring
BackgroundAlthough paternal exposure to cigarette smoke may contribute to obesity and metabolic syndrome in offspring, the underlying mechanisms...
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Influence of different weather aspects on breeding performance, food supply and nest-space use in hoopoe offspring
AbstractIn this study, we investigated the influence of different weather aspects on breeding performance, food supply and nest-space use in hoopoe...
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Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase
Retinoic acid-related orphan receptor alpha (RORA) suppression is associated with autism spectrum disorder (ASD) development, although the mechanism...
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Associations Between the Lead Level in Maternal Blood and Umbilical Cord Blood and Congenital Heart Diseases in Offspring
The incidence of congenital heart diseases (CHDs) shows an increasing trend and results in large health burdens in China. However, there have been...
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Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring
A surprising and well-replicated result in genetic studies of human longevity is that centenarians appear to carry disease-associated variants in...
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Association between maternal blood lipids and neonatal hypoglycaemia in pregnancy with gestational diabetes mellitus: a cohort study
BackgroundGestational diabetes mellitus (GDM) prevalence is on the rise globally. Offspring of diabetic mothers face increased risk of neonatal...
