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Identification of two key UDP-glycosyltransferases responsible for the ocotillol-type ginsenoside majonside-R2 biosynthesis in Panax vietnamensis var. fuscidiscus
Main conclusionTwo UDP-glycosyltransferases from Panax vienamensis var. fuscidiscus involved in ocotillol-type ginsenoside MR2 (majonside-R2)...
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HPLC-MS Analysis of Ginsenosides in Morphogenic Cell Cultures of Ginseng (Panax ginseng C.A. Meyer)
AbstractThe composition of triterpene glycosides in different in vitro tissues of cell lines (PgR–rhizogenic and PgG–hemogenic) and roots of ginseng...
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Pharmacological properties of ginsenosides in inflammation-derived cancers
Ginseng is commonly used as an herbal medicine for improvement of life quality. It is also used as a supplemental medication with anti-cancer drugs...
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Two important Ginseng plants in Southeast Asia: a systematic review of their traditional uses, botany, phytochemistry, and pharmacology
Panax vietnamensis (PV) and Panax stipuleanatus (PS) are important species of the Panax genus. In Vietnamese folk medicine, PV is regarded as a...
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Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis
Panax ginseng is a medicinal plant belonging to the Araliaceae family. Ginseng is known as the king of oriental medicine, which has been practiced...
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Differential expression of ginsenoside biosynthesis-related genes at an early developmental stage of Panax vietnamensis
Panax vietnamensis Ha et Grushv., an important medicinal plant in Vietnam, consists of several valuable ginsenosides. Compared to other Panax ...
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Production of ginsenoside compound K by microbial cell factory using synthetic biology-based strategy: a review
Ginsenoside compound K (CK) is a major intestinal bacterial metabolite of the protopanaxadiol-type ginsenoside family that can be absorbed in the...
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Novel ocotillol-derived lactone derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism
A new series of ocotillol-derived lactone derivatives were designed and synthesized to consider their antibacterial activity, structure–activity...
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Biocatalytic strategies for the production of ginsenosides using glycosidase: current state and perspectives
AbstractPanax ginseng is a traditional Chinese medicine with significant pharmaceutical effects and broad application. Rare ginsenosides with high...
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Identification and RNAi-based gene silencing of a novel UDP-glycosyltransferase from Panax quinquefolius
Panax quinquefolius ( P. quinquefolius ) has been used as medicine for thousands of years in Asia. Ginsenosides are major pharmacological active...
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Chemical components of ginseng, their biotransformation products and their potential as treatment of hypertension
Ginseng is an ancient perennial herb belonging to the family Araliaceae and genus Panax which has been used for medical therapeutics for thousands of...
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Functional characterization of genes related to triterpene and flavonoid biosynthesis in Cyclocarya paliurus
Main conclusionThe oxidosqualene cyclases (OSCs) generating triterpenoid skeletons in Cyclocarya paliurus were identified for the first time, and...
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Gut Microbiome for Ginseng Medicine
In the past few decades, using traditional Chinese medicines (TCMs), including Panax ginseng as pharmaceutical, nutraceutical, and healthcare...
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De novo whole-genome assembly and discovery of genes involved in triterpenoid saponin biosynthesis of Vietnamese ginseng (Panax vietnamensis Ha et Grushv.)
Vietnamese ginseng ( Panax vietnamensis Ha et Grushv.), also known as Ngoc Linh ginseng, is a high-value herb in Vietnam. Vietnamese ginseng has been...
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Drug-herb combination therapy in cancer management
Cancer is the second leading cause of fatality all over the world. Various unwanted side effects are being reported with the use of conventional...
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An Update to the Transcriptome Sequencing for the Genus Panax
Transcriptome sequencing for the non-model plants is currently becoming a preliminary data that assists the researchers in getting an initial glimpse...
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Biotechnology Towards Improvement of Plants for Enhancement of Natural Products
With an increased awareness and affinity towards plant-based natural products for various industrial applications, there is a substantial rise in the...
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Transcriptome analysis of Panax zingiberensis identifies genes encoding oleanolic acid glucuronosyltransferase involved in the biosynthesis of oleanane-type ginsenosides
Main conclusionOleanolic acid glucuronosyltransferase (OAGT) genes synthesizing the direct precursor of oleanane-type ginsenosides were discovered....
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Isolation of endophytes from Dioscorea nipponica Makino for stimulating diosgenin production and plant growth
Key messageBoth bacterial and fungal endophytes exhibited one or more plant growth-promoting (PGP) traits. Among these strains, the Paenibacillus...
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Activity and function studies of the promoter cis-acting elements of the key enzymes in saponins biosynthesis of DS from Panax notoginseng
AbstractPanax notoginseng is a traditional Chinese medicine for the treatment of blood diseases, in which saponins were the main active components....
