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Die Rolle von OPA1 bei der Fusion von Mitochondrien
Mitochondria form extensive networks that rapidly adapt to cellular demands. The formation and disassembly of these structures result from a balance...
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Cardiac-specific PFKFB3 overexpression prevents diabetic cardiomyopathy via enhancing OPA1 stabilization mediated by K6-linked ubiquitination
Diabetic cardiomyopathy (DCM) is a prevalent complication of type 2 diabetes (T2D). 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) is...
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Metabolic reprogramming in the OPA1-deficient cells
OPA1, a dynamin-related GTPase mutated in autosomal dominant optic atrophy, is essential for the fusion of the inner mitochondrial membrane. Although...
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The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice
Dominant optic atrophy (DOA) is one of the most prevalent forms of hereditary optic neuropathies and is mainly caused by heterozygous variants in OPA1 ...
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Inhibition of the mitochondria-sha** protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
Drug resistance limits the efficacy of chemotherapy and targeted cancer treatments, calling for the identification of druggable targets to overcome...
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OPA1 drives macrophage metabolism and functional commitment via p65 signaling
Macrophages are essential players for the host response against pathogens, regulation of inflammation and tissue regeneration. The wide range of...
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Empagliflozin improves renal ischemia–reperfusion injury by reducing inflammation and enhancing mitochondrial fusion through AMPK–OPA1 pathway promotion
BackgroundRenal ischemia–reperfusion injury (IRI) is one reason for renal transplantation failure. Recent studies have shown that mitochondrial...
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TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis
Mitochondrial function and homeostasis are critical to the proliferation of lung cancer cells. T-cell immunoglobulin and mucin domain-containing...
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Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons
Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining...
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FGF21-FGFR1 controls mitochondrial homeostasis in cardiomyocytes by modulating the degradation of OPA1
Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone secreted primarily by the liver and is considered a major regulator of energy...
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The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites
White to brown/beige adipocytes conversion is a possible therapeutic strategy to tackle the current obesity epidemics. While mitochondria are key for...
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Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space
Mitochondria, double-membrane organelles, are known to participate in a variety of metabolic and signal transduction pathways. The intermembrane...
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Pathogenicity evaluation and the genotype–phenotype analysis of OPA1 variants
Autosomal dominant optic atrophy (ADOA) is an important cause of irreversible visual impairment in children and adolescents. About 60–90% of ADOA is...
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Deletion of the mitochondria-sha** protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism
Optic atrophy 1 (OPA1), a mitochondria-sha** protein controlling cristae biogenesis and respiration, is required for memory T cell function, but...
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OPA1 and MICOS Regulate mitochondrial crista dynamics and formation
Mitochondrial cristae are the main site for oxidative phosphorylation, which is critical for cellular energy production. Upon different physiological...
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Drugs targeting TGF-β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion
Hypertrophic scar (HS) formation is a cutaneous fibroproliferative disease that occurs after skin injuries and results in severe functional and...
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Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1
The mitochondrion is a highly dynamic organelle that is critical for energy production and numerous metabolic processes. Drosophila Chchd2 , a homolog...
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Silibinin treatment results in reducing OPA1&MFN1 genes expression in a rat model hepatic ischemia–reperfusion
The mitochondrial damage has a pivotal role in triggering apoptosis and cell death. This study assessed the effect of silibinin on optical atrophy-1...
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Stimulated Microgravity Affects Mitochondrial Homeostasis in the Harderian Glands of Mice
AbstractLong-term exposure to microgravity can cause alterations in the structure and function of the eyes, including the Harderian glands (HG) which...
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OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases
Prion diseases caused by the cellular prion protein (PrP C ) conversion into a misfolded isoform (PrP Sc ) are associated with multiple mitochondrial...
