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Mesencephalic astrocyte-derived neurotrophic factor inhibits cervical cancer progression via regulating macrophage phenotype
BackgroundCervical cancer is a common gynecologic malignant tumor, but the critical factors affecting cervical cancer progression are still not well...
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Neurotrophic Biomarkers
Neurotrophins are proteins that exert profound effects on cell survival and activity within the central nervous system, playing crucial roles in the...
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Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry
Plasticity and homeostatic mechanisms allow neural networks to maintain proper function while responding to physiological challenges. Despite...
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Effect of Hippocampal Overexpression of Dopamine Neurotrophic Factor (CDNF) on Behavior of Mice with Genetic Predisposition to Depressive-Like Behavior
AbstractCerebral dopamine neurotrophic factor (CDNF) is a promising agent for Parkinson’s disease treatment. However, its role in regulation of...
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Association of indoleamine 2,3 dioxygenase, brain derived neurotrophic factor and cellular senescence in type 2 diabetes mellitus with depression: a clinical approach
Background and aimType 2 diabetes mellitus (T2DM) and depression are often linked. Several studies have reported the role of molecular markers either...
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Stable and efficient expression of human brain-derived neurotrophic factor in tobacco chloroplasts
BackgroundBrain-derived neurotrophic factor (BDNF) is an intensively studied neurotrophin that promotes various physiological processes, such as...
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Influence of stimulation frequency on brain-derived neurotrophic factor and cathepsin-B production in healthy young adults
Electrical muscle stimulation (EMS) has been shown to stimulate the production of myokines (i.e., brain-derived neurotrophic factor (BDNF)), but the...
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Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential
AbstractThe cerebral dopamine neurotrophic factor (CDNF) together with the mesencephalic astrocyte-derived neurotrophic factor (MANF) form a unique...
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Human platelet lysate stimulates neurotrophic properties of human adipose-derived stem cells better than Schwann cell-like cells
BackgroundTrauma-associated peripheral nerve injury is a widespread clinical problem causing sensory and motor disabilities. Schwann cells (SCs)...
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Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats
BackgroundThyroid hormones play a vital function in the maturation in the course of mind development. Regarding the well-known effects of choline on...
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Intra-amniotic transplantation of brain-derived neurotrophic factor-modified mesenchymal stem cells treatment for rat fetuses with spina bifida aperta
BackgroundSpina bifida aperta (SBA) is a relatively common clinical type of neural tube defect. Although prenatal fetal surgery has been proven to be...
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Spirulina Platensis Alleviates γ- Radiation-Induced Brain Damage by Attenuating Oxidative Stress and Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels in Male Albino Rats
Ionizing radiation can irreversibly damage the brain cells’ function and structure. Spirulina platensis (Sp) is widely employed as a dietary...
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Chronic social comparison elicits depression- and anxiety-like behaviors and alterations in brain-derived neurotrophic factor expression in male rats
Social comparison is a fundamental human characteristic; however, long-term social comparison may induce psychological stress and can lead to...
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Association of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism with Individual Alpha Peak Frequency and Alpha Power in Adults
Abstract —A single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene ( Val66Met ) functions to regulate activity-dependent...
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Mesencephalic astrocyte-derived neurotrophic factor reprograms macrophages to ameliorate acetaminophen-induced acute liver injury via p38 MAPK pathway
Acetaminophen (APAP)-induced liver injury (AILI) is the most frequent cause of acute liver failure; but the underlying mechanisms still remain...
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Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model
BackgroundSpinal cord injury (SCI) is a disease that causes permanent impairment of motor, sensory, and autonomic nervous system functions. Stem cell...
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Erratum to: Association of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism with Individual Alpha Peak Frequency and Alpha Power in Adults
An Erratum to this paper has been published: https://doi.org/10.1134/S0362119723970017
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Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling
BackgroundMaturation is a process that allows synapses to acquire full functionality, optimizing their activity to diverse neural circuits, and...
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Neurotrophic factor-secreting cells restored endogenous hippocampal neurogenesis through the Wnt/β-catenin signaling pathway in AD model mice
BackgroundImpairment in neurogenesis correlates with memory and cognitive dysfunction in AD patients. In the recent decade, therapies with stem cell...
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Involvement of Rac1 in macrophage activation by brain-derived neurotrophic factor
Brain-derived neurotrophic factor (BDNF) enhances periodontal tissue regeneration. Tissue regeneration is characterized by inflammation, which...
