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Biomimetic nerve guidance conduit containing engineered exosomes of adipose-derived stem cells promotes peripheral nerve regeneration
BackgroundEfficient and stable delivery of neurotrophic factors (NTFs) is crucial to provide suitable microenvironment for peripheral nerve...
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Application of Human Epineural Conduit Supported with Human Mesenchymal Stem Cells as a Novel Therapy for Enhancement of Nerve Gap Regeneration
Various therapeutic methods have been suggested to enhance nerve regeneration. In this study, we propose a novel approach for enhancement of nerve...
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Peripheral Nerve Regeneration Using a Nerve Conduit with Olfactory Ensheathing Cells in a Rat Model
BACKGROUND:Autologous nerve grafts are the gold standard treatment for peripheral nerve injury treatment. However, this procedure cannot avoid...
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Artificial Nerve Containing Stem Cells, Vascularity and Scaffold; Review of Our Studies
To promote nerve regeneration within a conduit (tubulation), we have performed studies using a tube model based on four important concepts for tissue...
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Potential Application of Orofacial MSCs in Tissue Engineering Nerve Guidance for Peripheral Nerve Injury Repair
Injury to the peripheral nerve causes potential loss of sensory and motor functions, and peripheral nerve repair (PNR) remains a challenging...
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Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration
BACKGROUND:Repair of long-distance peripheral nerve defects remains an important clinical problem. Nerve grafts incorporated with extracellular...
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Transplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury
Background:Stem cell-based transplantation therapy holds promise for peripheral nerve injury treatment, but adult availability is limited. A cell...
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Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models
BACKGROUND:Peripheral nerve damage mainly resulted from traumatic or infectious causes; the main signs of a damaged nerve are the loss of sensory...
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Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration
BackgroundNerve guide conduits are a promising strategy for reconstructing peripheral nerve defects. Improving the survival rate of seed cells in...
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Cell Technologies in Experimental Therapy of Nerve Injuries (Problematic–Analytical Review)
Abstract —This review is devoted to a topical problem of damaged nerve repair using stem cells. It presents the analysis the author’s data and...
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Functional tissue-engineered microtissue formed by self-aggregation of cells for peripheral nerve regeneration
BackgroundPeripheral nerve injury (PNI) is one of the essential causes of physical disability with a high incidence rate. The traditional tissue...
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Cell-free therapy based on extracellular vesicles: a promising therapeutic strategy for peripheral nerve injury
Peripheral nerve injury (PNI) is one of the public health concerns that can result in a loss of sensory or motor function in the areas in which...
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Transplanted neural lineage cells derived from dental pulp stem cells promote peripheral nerve regeneration
Cell therapy for peripheral nerve injury is a promising strategy as regenerative medicine that restores neurological function. However, challenges...
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Transcription and proteome changes involved in re-innervation muscle following nerve crush in rats
Severe peripheral nerve injury leads to the irreparable disruption of nerve fibers. This leads to disruption of synapses with the designated muscle,...
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Augmenting Peripheral Nerve Regeneration with Adipose-Derived Stem Cells
Peripheral nerve injuries (PNIs) are common and debilitating, cause significant health care costs for society, and rely predominately on autografts,...
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Comparison of two different decellularization methods for processed nerve allograft
The use of processed nerve allografts as an alternative to autologous nerve grafts, the gold standard treatment for peripheral nerve defects, is...
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Effectiveness and Biocompatibility of Decellularized Nerve Graft Using an In Vivo Rat Sciatic Nerve Model
Background:Decellularized nerve allografting is one of promising treatment options for nerve defect. As an effort to develop more efficient nerve...
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Inverted human umbilical artery as a 3D scaffold for sciatic nerve regeneration in rats
Treatment of peripheral nerve injuries (PNIs) remains a challenge. Interposing a graft delivers better regenerative outcomes. Autografts present...
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Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury
Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory...
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Comparative study of decellularization techniques to obtain natural extracellular matrix scaffolds of human peripheral-nerve allografts
BackgroundWe hypothesize that adding sonication cycles to the process of decellularization of cadaveric human peripheral nerves will increase the...
