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CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells
Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the...
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The RNA m6A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer
N 6 -methyladenosine (m 6 A) and its associated reader protein insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) are involved in tumor...
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NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells
IntroductionCytokines of the common γ chain (γc) family are critical for the development, differentiation, and survival of T lineage cells. Cytokines...
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Xanthotoxol from Saussurea obvallata Attenuates LPS-Induced RAW 264.7 Cells Inflammatory Responses through NF-κB Pathway
AbstractSaussurea obvallata has been used as a medicinal herb to treat rheumatoid arthritis in Qinghai-Tibet Plateau. Xanthotoxol, one of the major...
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CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth
Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders...
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Integrated compact regulators of protein activity enable control of signaling pathways and genome-editing in vivo
Viral proteases and clinically safe inhibitors were employed to build integrated compact regulators of protein activity (iCROP) for...
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NFAT1-regulated IL6 signalling contributes to aggressive phenotypes of glioma
BackgroundWe previously demonstrated that the local immune status correlated with the glioma prognosis. Interleukin-6 (IL6) was identified as an...
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Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement
ObjectiveThe immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant...
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Increased HERV-E clone 4–1 expression contributes to DNA hypomethylation and IL-17 release from CD4+ T cells via miR-302d/MBD2 in systemic lupus erythematosus
BackgroundIncreased human endogenous retroviruses E clone 4–1 (HERV-E clone 4–1) mRNA expression is observed in systemic lupus erythematosus (SLE)...
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Monitoring VEGF-Stimulated Calcium Ion Flux in Endothelial Cells
The endothelial response to vascular endothelial growth factor A (VEGF-A) regulates many aspects of animal physiology in health and disease. Such...
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Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7
The identification and development of therapeutic targets in cancer stem cells that lead to tumor development, recurrence, metastasis, and drug...
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RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2
Chronic kidney disease (CKD) is thus deemed to a global health problem. Renal fibrosis, characterized by accumulation of extracellular matrix (ECM)...
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Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling
T-cell-specific Rap1 deletion causes spontaneous colitis in mice. In the present study, we revealed that Rap1 deficiency in T cells impaired the...
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Discovery and Characterization of Linear Motif Mediated Protein-Protein Complexes
There are myriads of protein-protein complexes that form within the cell. In addition to classical binding events between globular domains, many...
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Author Correction: metabolic signaling in T cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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SUMOylation of PDPK1 Is required to maintain glycolysis-dependent CD4 T-cell homeostasis
The immune system is finely tuned to fight against infections, eradicate neoplasms, and prevent autoimmunity. Protein posttranslational modification...
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Cav2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization
Distant metastasis is the main cause of mortality in breast cancer patients. Using the breast cancer genomic data from The Cancer Genome Atlas...
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Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression
The transcriptional regulator nuclear factor of activated T-cells, cytoplasmic 3 (NFATc3) is constitutively activated in several cancer types and...
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CRZ1 transcription factor is involved in cell survival, stress tolerance, and virulence in fungi
The calcineurin-CRZ1 signaling pathway is conserved from yeasts to humans, and is involved in survival, tolerance to biotic and abiotic stress...
