Search
Search Results
-
Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria
BackgroundAnaplasma translocated substrate 1 (Ats-1) is an effector of type 4 secretory systems (T4SS) and the main virulence factor of Anaplasma...
-
Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
BackgroundPregnancy is a complicated physiological process. The multifaceted regulation of maternal–fetal interface is of great importance for...
-
Genome-wide selection signatures detection in Shanghai Holstein cattle population identified genes related to adaption, health and reproduction traits
BackgroundOver several decades, a wide range of natural and artificial selection events in response to subtropical environments, intensive pasture...
-
RNA-bindende Proteine als Regulatoren des Stammzellstoffwechsels
Differentiation of embryonic stem cells requires the coordinated regulation of their metabolism, which is characterised by a shift from glycolysis to...
-
Staufen1 controls mitochondrial metabolism via HIF2α in embryonal rhabdomyosarcoma and promotes tumorigenesis
Elevated mitochondrial metabolism promotes tumorigenesis of Embryonal Rhabdomyosarcomas (ERMS). Accordingly, targeting oxidative phosphorylation...
-
Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells
BackgroundCitrate Synthase ( Cs ) gene mutation (locus ahL4 ) has been found to play an important role in progressive hearing loss of A/J mice. HEI-OC1...
-
The matricellular protein CCN6 differentially regulates mitochondrial metabolism in normal epithelium and in metaplastic breast carcinomas
Metaplastic breast carcinoma (MBC) is an aggressive subtype of triple negative breast cancer with undefined precursors, limited response to...
-
Characterization of placental and decidual cell development in early pregnancy loss by single-cell RNA sequencing
BackgroundEarly pregnancy loss (EPL) presents as sporadic or recurrent miscarriage during the first trimester. In addition to chromosomal defects,...
-
AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling
BackgroundCardiac pathological outcome of metabolic remodeling is difficult to model using cardiomyocytes derived from human-induced pluripotent stem...
-
Current Insights into the Potential of Gene Therapy to Treat Rare Mitochondrial Diseases
Mitochondrial disorders represent a rare category of diseases that arise from abnormalities in essential proteins necessary for the proper...
-
-
METTLing in Stem Cell and Cancer Biology
The methyltransferase-like (METTL) family is a diverse group of methyltransferases that can methylate nucleotides, proteins, and small molecules....
-
Anaplasma phagocytophilum Ats-1 enhances exosome secretion through Syntenin-1
Anaplasma phagocytophilum is an intracellular obligate parasite that causes granulocytic anaplasmosis. Effector Ats-1 is an important virulence...
-
Time of exercise differentially impacts bone growth in mice
Although physical training has been shown to improve bone mass, the time of day to exercise for optimal bone growth remains uncertain. Here we show...
-
Gene expression profiling of trout muscle during flesh quality recovery following spawning
BackgroundSexual maturation causes loss of fish muscle mass and deterioration of fillet quality attributes that prevent market success. We recently...
-
An iron-dependent form of non-canonical ferroptosis induced by labile iron
Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death characterized by reactive oxygen species (ROS) generation and...
-
The assembly, regulation and function of the mitochondrial respiratory chain
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It comprises five enzymatic complexes and two mobile electron...
-
Genome of the pincer wasp Gonatopus flavifemur reveals unique venom evolution and a dual adaptation to parasitism and predation
BackgroundHymenoptera comprise extremely diverse insect species with extensive variation in their life histories. The Dryinidae, a family of solitary...
-
Regulatory roles of NAT10 in airway epithelial cell function and metabolism in pathological conditions
N-acetyltransferase 10 (NAT10), a nuclear acetyltransferase and a member of the GNAT family, plays critical roles in RNA stability and translation...
-
Alzheimer’s disease rewires gene coexpression networks coupling different brain regions
Connectome studies have shown how Alzheimer’s disease (AD) disrupts functional and structural connectivity among brain regions. But the molecular...
