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Mitral valve transcriptome analysis in thirty-four age-matched Cavalier King Charles Spaniels with or without congestive heart failure caused by myxomatous mitral valve disease
We here report the results of a mitral valve transcriptome study designed to identify genes and molecular pathways involved in development of...
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Perivascular inflammatory cells and their association with pulmonary arterial remodelling in dogs with pulmonary hypertension due to myxomatous mitral valve disease
Pulmonary hypertension (PH), an increase in pulmonary arterial pressure (PAP), may occur in dogs affected with myxomatous mitral valve disease...
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Database development and survival analysis in a clinical and historical cohort of dogs affected by myxomatous mitral valve disease treated or not with pimobendan using causal inference techniques
The aim of this work was to retrospectively evaluate the influence of pimobendan on the survival time (ST) of dogs with myxomatous mitral valve...
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Heart Valve Disease
This chapter was designed to provide the reader with a brief overview of the current treatment options for human heart valve disease. Major topics of...
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Neutrophil-to-lymphocyte ratio and red blood cell distribution width to platelet ratio and their relationships with inflammatory and antioxidant status in dogs with different stages of heart failure due to myxomatous mitral valve disease
We aimed to evaluate the red blood cell distribution width-to-platelet ratio (RDW/PLT) with other complete blood cell count (CBC) indices and their...
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Streptococcus canis prostatitis and endocarditis with thromboembolism in a dog with sertoli cell tumour in a cryptic testis and prostatic squamous metaplasia
We describe an unusual case of prostatitis caused by Streptococcus canis evolving to endocarditis and splenic, renal, and cerebral thromboembolism in...
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Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure
IntroductionMyxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and...
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Echocardiographic Imaging of Cardiac Valves
Perioperative echocardiography (echo) has become the imaging modality of choice during cardiac valve surgery. It is a very useful tool not only for...
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Disturbed energy and amino acid metabolism with their diagnostic potential in mitral valve disease revealed by untargeted plasma metabolic profiling
IntroductionMitral valve disease (MVD), including mitral valve regurgitation (MR) and mitral valve stenosis (MS), is a chronic and progressive...
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Tpeak—Tend, a novel electrocardiographic marker in cats with hypertrophic cardiomyopathy—a brief communication
Hypertrophic cardiomyopathy (HCM) is the most common heart disease in feline species. ECG allows assessing parameters that can help in the diagnosis...
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MiRNA miR-375 as a Multifunctional Regulator of the Cardiovascular System
AbstractMicroRNA (miRNA) miR-375 acts as a multifunctional regulator of the activity of many physiological and pathological cellular processes by...
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QT interval instability and variability in dogs with naturally-occurring hypercortisolism
Hypercortisolism is one of the most common endocrine diseases in dogs. In humans, it is clearly associated with a higher risk of cardiovascular...
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Molecular and Cellular Developments in Heart Valve Development and Disease
The prevalence of heart valve disease is estimated at 2.5% and this number is likely to increase with the steady rise in life expectancy and...
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Mouse models of spontaneous atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia in adults, with a prevalence increasing with age. Current clinical management of AF is focused...
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Biological Mechanics of the Heart Valve Interstitial Cell
Heart valves are composed of multilayered tissues that contain a population of vascular endothelial cells (VEC) on the blood contacting surfaces and...
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The Role of Proteoglycans and Glycosaminoglycans in Heart Valve Biomechanics
Proteoglycans (PGs) and glycosaminoglycans (GAGs) have long been recognized as constituents of heart valves but their precise functions have been...
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Hypertension and the Heart and Vasculature
The importance of the heart as a target for end-organ damage in hypertensive disease has long been recognized. This chapter describes the structural...
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Measurement Technologies for Heart Valve Function
Experimental measurement technologies have been critical to advancing scientific knowledge and to the development of prosthetic heart valve devices....
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Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease
Heart valves are elegant, dynamic, pliable structures experiencing complex and varied mechanical forces during development and throughout the course...
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Pharmacology of Antihypertensive Drugs
The clinical pharmacology of antihypertensive drugs in general is reviewed. Particular attention is given to the drugs which inhibit...