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MicroRNA-668-3p inhibits myoblast proliferation and differentiation by targeting Appl1
BackgroundSkeletal muscle is the largest tissue in the body, and it affects motion, metabolism and homeostasis. Skeletal muscle development comprises...
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Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation
BackgroundMyoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The...
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Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene
BackgroundHypoxia is known to modify skeletal muscle biological functions and muscle regeneration. However, the mechanisms underlying the effects...
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p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence
During aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible...
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Slc2a6 regulates myoblast differentiation by targeting LDHB
BackgroundType 2 diabetes mellitus is a global health problem. It often leads to a decline in the differentiation capacity of myoblasts and...
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The retinoic acid response is a minor component of the cardiac phenotype in H9c2 myoblast differentiation
The H9c2 myoblast cell line, isolated from the left ventricular tissue of rat, is currently used in vitro as a mimetic for skeletal and cardiac...
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Implication of N-glycolylneuraminic acid in regulation of cell adhesiveness of C2C12 myoblast cells during differentiation into myotube cells
A transition of sialic acid (Sia) species on GM3 ganglioside from N -acetylneuraminic acid (Neu5Ac) to N -glycolylneuraminic acid (Neu5Gc) takes place...
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BVES is a novel interactor of ANO5 and regulates myoblast differentiation
BackgroundAnoctamin 5 (ANO5) is a membrane protein belonging to the TMEM16/Anoctamin family and its deficiency leads to the development of limb...
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Establishment and characterization of a skeletal myoblast cell line of grass carp (Ctenopharyngodon idellus)
Skeletal muscle myoblastic cell lines can provide a valuable new in vitro model for the exploration of the mechanisms that control skeletal muscle...
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Cold-shock proteome of myoblasts reveals role of RBM3 in promotion of mitochondrial metabolism and myoblast differentiation
Adaptation to hypothermia is important for skeletal muscle cells under physiological stress and is used for therapeutic hypothermia (mild hypothermia...
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Stiff matrices enhance myoblast proliferation, reduce differentiation, and alter the response to fluid shear stress in vitro
During myofiber regeneration, myoblasts are continuously subjected to shear stress. It is currently not known whether shear stress affects the...
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Human Myoblast Genome Therapy and the Regenerative Heart
Heart muscle degeneration leading to heart failure is one of the most debilitating and fatal conditions affecting mankind. Over the past 22 years,...
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Expression patterns and correlation analyses of muscle-specific genes in the process of sheep myoblast differentiation
The purpose of this study was to establish a system for the isolation, culture, and differentiation of sheep myoblasts, and to explore the expression...
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Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion
The fusion of mononucleated myoblasts produces multinucleated muscle fibers leading to the formation of skeletal muscle. Myomaker, a skeletal...
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Chromatin profiling reveals TFAP4 as a critical transcriptional regulator of bovine satellite cell differentiation
BackgroundSatellite cells are myogenic precursor cells in adult skeletal muscle and play a crucial role in skeletal muscle regeneration, maintenance,...
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A first-in-human clinical study of laparoscopic autologous myoblast sheet transplantation to prevent delayed perforation after duodenal endoscopic mucosal dissection
BackgroundThe detection rate of superficial non-ampullary duodenal epithelial tumors (SNADETs) has recently been increasing. Large tumors may contain...
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2-D08 treatment regulates C2C12 myoblast proliferation and differentiation via the Erk1/2 and proteasome signaling pathways
SUMOylation is one of the post-translational modifications that involves the covalent attachment of the small ubiquitin-like modifier (SUMO) to the...
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MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation
BackgroundSarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited...
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The Maintenance of AMPK Activity Eliminates Abnormally Accelerated Differentiation of Primary Myoblasts Isolated from Atrophied Rat Soleus Muscle
AbstractMechanical unloading of skeletal muscles leads to the development of atrophic processes and a decrease in the total number of...
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Downregulated hypoxia-inducible factor 1α improves myoblast differentiation under hypoxic condition in mouse genioglossus
The treatment of obstructive sleep apnea–hypopnea syndrome targets the narrow anatomic structure of the upper airway (UA) and lacks an effective...
