Search
Search Results
-
Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer’s Disease Signs Development
AbstractGABA and glutamate are the most abundant neurotransmitters in the CNS and play a pivotal part in synaptic stability/plasticity. Glutamate and...
-
Glutamate and GABA Receptors of Nerveless Animals (Placozoa): Preadaptation to Neurotransmission
Abstract —The emergence of the nervous system is one of the most important events in the evolution of life on Earth. The details of this event remain...
-
The Functional State of Glutamate- and GABA-Ergic Neurons in the Inferior Colliculi of Krushinsky–Molodkina Rats at Early Stages of Epileptogenesis
AbstractDisturbances in the neurotransmitter systems associated with the development of temporal lobe epilepsy (TLE) have been well-studied in...
-
nNOS in Erbb4-positive neurons regulates GABAergic transmission in mouse hippocampus
Neuronal nitric oxide synthase (nNOS, gene name Nos1) orchestrates the synthesis of nitric oxide (NO) within neurons, pivotal for diverse neural...
-
Role of sodium dependent SLC13 transporter inhibitors in various metabolic disorders
The sodium dependent SLC13 family transporters comprise of five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 (NaCT). Among...
-
Spectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
Fast synaptic inhibition is dependent on targeting specific GABA A R subtypes to dendritic and axon initial segment (AIS) synapses. Synaptic GABA A Rs...
-
Predicting intercellular communication based on metabolite-related ligand-receptor interactions with MRCLinkdb
BackgroundMetabolite-associated cell communications play critical roles in maintaining human biological function. However, most existing tools and...
-
Exercise Ameliorates Fluoride-induced Anxiety- and Depression-like Behavior in Mice: Role of GABA
Fluoride exposure caused anxiety- and depression-like behavior in mice. Meanwhile, exercise contributes to relieve anxiety and depression. However,...
-
Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models
The global COVID-19 epidemic has spread rapidly around the world and caused the death of more than 5 million people. It is urgent to develop...
-
Ameliorative effects of probiotics in AlCl3-induced mouse model of Alzheimer’s disease
AbstractIn recent years, gut microbiome alterations have been linked with complex underlying mechanisms of neurodegenerative disorders including...
-
A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles
Physiologically, the atria contract first, followed by the ventricles, which is the prerequisite for normal blood circulation. The above phenomenon...
-
Analysis of the Functional State of Astroglia in the Hippocampus of Rats Genetically Prone to Audiogenic Seizures
AbstractIt was shown that abnormalities in astrocyte functions can cause alterations in neuronal excitability and promote the development of...
-
Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling
BackgroundOxytocin, secreted by oxytocin neurons in the hypothalamus, is an endogenous neuropeptide involved in modulating multiple sensory...
-
Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson’s disease
Parkinson’s disease (PD) is a progressive movement disorder characterized by dopaminergic (DA) neuron degeneration and the existence of Lewy bodies...
-
Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7
The identification and development of therapeutic targets in cancer stem cells that lead to tumor development, recurrence, metastasis, and drug...
-
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic...
-
Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability
In recent years, primary familial brain calcification (PFBC), a rare neurological disease characterized by a wide spectrum of cognitive disorders,...
-
Exploring neuronal mechanisms involved in the scratching behavior of a mouse model of allergic contact dermatitis by transcriptomics
BackgroundAllergic contact dermatitis (ACD) is a common skin condition characterized by contact hypersensitivity to allergens, accompanied with skin...
-
Ectopic activation of GABAB receptors inhibits neurogenesis and metamorphosis in the cnidarian Nematostella vectensis
The metabotropic gamma-aminobutyric acid B receptor (GABA B R) is a G protein-coupled receptor that mediates neuronal inhibition by the...
-
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiological and psychiatric...
