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Microbial production of valuable chemicals by modular co-culture strategy
Nowadays, microbial synthesis has become a common way for producing valuable chemicals. Traditionally, microbial production of valuable chemicals is...
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Effects of rice-prawn (Macrobrachium nipponense) co-culture on the microbial community of soil
AbstractIn the Lixiahe region of China, co-culture has been rapidly promoted in flooded paddy fields owing to its ecological and economic benefits....
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The effects of co-culture on the expression of selected PKS genes in the lichenized fungus Xanthoparmelia taractica
Lichens produce diverse secondary metabolites. A diversity of these compounds is synthesized by fungal polyketide synthases (PKSs). In this study, we...
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Bioproduction of eriodictyol by Escherichia coli engineered co-culture
AbstractEriodictyol (ED) is a flavonoid in the flavanones subclass. It is abundantly present in a wide range of medicinal plants, citrus fruits, and...
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Direct delivery and fast-treated Agrobacterium co-culture (Fast-TrACC) plant transformation methods for Nicotiana benthamiana
There is an expanding need to modify plant genomes to create new plant germplasm that advances both basic and applied plant research. Most current...
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De novo biosynthesis of complex natural product sakuranetin using modular co-culture engineering
AbstractFlavonoids are a large family of plant and fungal natural products, among which many have been found to possess outstanding biological...
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Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression
Recent findings have implicated long noncoding RNAs (lncRNAs) as pivotal gene regulators for diverse biological processes, despite their lack of...
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Modular, programmable RNA sensing using ADAR editing in living cells
With the increasing availability of single-cell transcriptomes, RNA signatures offer a promising basis for targeting living cells. Molecular RNA...
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Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains
Despite unequivocal roles in disease, transcription factors (TFs) remain largely untapped as pharmacologic targets due to the challenges in targeting...
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Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction
With the advent of increasingly sophisticated organoids, there is growing demand for technology to replicate the interactions between multiple...
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Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution
The dry mass and the orientation of biomolecules can be imaged without a label by measuring their permittivity tensor (PT), which describes how...
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Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins
Targeted degradation of cell surface and extracellular proteins via lysosomal delivery is an important means to modulate extracellular biology....
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ABC-transporter CFTR folds with high fidelity through a modular, stepwise pathway
The question how proteins fold is especially pointed for large multi-domain, multi-spanning membrane proteins with complex topologies. We have...
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Controlled release of growth factors using synthetic glycosaminoglycans in a modular macroporous scaffold for tissue regeneration
Healthy regeneration of tissue relies on a well-orchestrated release of growth factors. Herein, we show the use of synthetic glycosaminoglycans for...
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A modular two yeast species secretion system for the production and preparative application of unspecific peroxygenases
Fungal unspecific peroxygenases (UPOs) represent an enzyme class catalysing versatile oxyfunctionalisation reactions on a broad substrate scope. They...
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A modular microfluidic bioreactor to investigate plant cell–cell interactions
Plants produce a wide variety of secondary metabolites, which often are of interest to pharmaceutical and nutraceutical industry. Plant-cell cultures...
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Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture
Chromosome conformation capture (3C) methods measure the spatial proximity between DNA elements in the cell nucleus. Many methods have been developed...
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VEBA: a modular end-to-end suite for in silico recovery, clustering, and analysis of prokaryotic, microeukaryotic, and viral genomes from metagenomes
BackgroundWith the advent of metagenomics, the importance of microorganisms and how their interactions are relevant to ecosystem resilience,...
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Design, Characterization, and Application of Targeted Gene Activation in Bacteria Using a Modular CRISPRa System
CRISPR-Cas regulators have provided an excellent toolbox to control gene expression due to the versatility of its components and the easy programming...
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Modular Assembly of Mitochondrial β-Barrel Proteins
Mitochondrial β-barrel proteins fulfill crucial roles in the biogenesis and function of the cell organelle. They mediate the import and membrane...